Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)

• Published in: JNCI : Journal of the National Cancer Institute 2025-01, Vol.117 (1), p.9-19
• Main Authors: Schmitz, Kathryn H, Brown, Justin C, Irwin, Melinda L, Robien, Kim, Scott, Jessica M, Berger, Nathan A, Caan, Bette, Cercek, Andrea, Crane, Tracy E, Evans, Scott R, Ligibel, Jennifer A, Meyerhardt, Jeffrey A, Agurs-Collins, Tanya, Basen-Engquist, Karen, Bea, Jennifer W, Cai, Sheng F, Cartmel, Brenda, Chinchilli, Vernon M, Demark-Wahnefried, Wendy, Dieli-Conwright, Christina M, DiPietro, Loretta, Doerksen, Shawna E, Edelstein, Sharon L, Elena, Joanne, Evans, William, Ferrucci, Leah M, Foldi, Julia, Freylersythe, Sarah, Furberg, Helena, Jones, Lee W, Levine, Ross, Moskowitz, Chaya S, Owusu, Cynthia, Penedo, Frank, Rabin, Borsika A, Ratner, Elena, Rosenzweig, Margaret, Salz, Talya, Sanft, Tara, Schlumbrecht, Matthew, Spielmann, Guillaume, Thomson, Cynthia A, Tjaden, Ashley H, Weiser, Martin R, Yang, Shengping, Yu, Anthony F, Perna, Frank M
• Format: Article
• Language: English
• Subjects: Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Exercise; Exercise Therapy; Fatigue - etiology; Fatigue - therapy; Humans; National Cancer Institute (U.S.); Neoplasms - therapy; Nutritional Status; Quality of Life; Treatment Outcome; United States
• ISSN: 0027-8874; 1460-2105; 1460-2105
• DOI: 10.1093/jnci/djae177

Chemotherapy treatment-related side effects are common and increase the risk of suboptimal outcomes. Exercise interventions during cancer treatment improve self-reported physical functioning, fatigue, anxiety, and depression, but it is unclear whether these interventions improve important clinical outcomes, such as chemotherapy relative dose intensity. The National Cancer Institute funded the Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO) Consortium to address this knowledge gap. This article describes the mechanisms hypothesized to underpin intervention effects on clinically relevant treatment outcomes, briefly outlines each project's distinct research aims, summarizes the scope and organizational structure of ENICTO, and provides an overview of the integrated common data elements used to pursue research questions collectively. In addition, the article includes a description of consortium-wide activities and broader research community opportunities for collaborative research. Findings from the ENICTO Consortium have the potential to accelerate a paradigm shift in oncology care such that patients with cancer could receive exercise and nutrition programming as the standard of care in tandem with chemotherapy to improve relative dose intensity for a curative outcome.