Indications and Outcomes of Fetal Cystoscopy for Lower Urinary Tract Obstruction: A Comprehensive Review

• Published in: Prenatal diagnosis 2025-01, Vol.45 (1), p.89-101
• Main Authors: Pierucci, Ugo Maria, Paraboschi, Irene, Lanfranchi, Giulia, Peycelon, Matthieu, Pelizzo, Gloria, Ruano, Rodrigo
• Format: Article
• Language: English
• Subjects: bladder outlet obstruction; Congenital anomalies; congenital anomalies of the kidney and urinary tract; Congenital defects; Cystoscopy - methods; Female; fetal cystoscopy; Fetal Diseases - diagnosis; Fetal Diseases - diagnostic imaging; Fetal Diseases - surgery; fetal surgery; Fetal Therapy; fetal vesicoamniotic shunt; Fetuses; Humans; Hypoplasia; lower urinary tract obstruction; megacystis; Morbidity; Obstructions; Pregnancy; prenatal diagnosis; Renal function; Review; ultrasound; Urethral Obstruction - diagnosis; Urethral Obstruction - diagnostic imaging; Urethral Obstruction - surgery; Urinary tract; Urogenital system
• ISSN: 0197-3851; 1097-0223; 1097-0223
• DOI: 10.1002/pd.6721

ABSTRACT Fetal lower urinary tract obstruction (LUTO) encompasses a spectrum of rare congenital anomalies affecting the fetal urinary system, leading to significant morbidity and mortality. This condition, arising from various anatomical anomalies such as posterior urethral valves (PUV), urethral atresia, and cloacal malformations, disrupts normal urine flow, resulting in secondary complications such as pulmonary hypoplasia and renal impairment. Current management strategies, including fetal vesicoamniotic shunting (VAS) and fetal cystoscopy, aim to alleviate obstruction and mitigate associated risks. While VAS has been a longstanding intervention, fetal cystoscopy presents a promising alternative by enabling direct visualization and targeted treatment of urinary tract obstructions. However, fetal cystoscopy is not without challenges, including technical complexities and risks associated with invasive procedures. This review explores the rationale, indications, technical considerations, outcomes, and future innovations of fetal cystoscopy in managing LUTO. It highlights the critical role of accurate diagnosis, patient selection, and procedural expertise in optimizing fetal and maternal outcomes. Despite existing challenges, ongoing advancements in technology and clinical practice hold the potential for further enhancing the safety and efficacy of fetal cystoscopy, underscoring its evolving role in prenatal care.