Impact of isolated fetal congenital heart disease on pregnancy and perinatal outcomes

• Published in: International journal of gynecology and obstetrics 2025-02, Vol.168 (2), p.790-799
• Main Authors: Kittiratanapinan, Yossawadee, Anuwutnavin, Sanitra, Kanjanauthai, Supaluck, Wutthigate, Punnanee, Boriboonhirunsarn, Dittakarn, Chawanpaiboon, Saifon
• Format: Article
• Language: English
• Subjects: Adult; adverse pregnancy outcomes; Case-Control Studies; Clinical; congenital heart disease; Female; Heart Defects, Congenital - epidemiology; Humans; Infant, Newborn; Infant, Small for Gestational Age; Obstetric Labor, Premature - epidemiology; Pre-Eclampsia - epidemiology; Pregnancy; Pregnancy Outcome - epidemiology; Premature Birth - epidemiology; prenatal diagnosis; preterm delivery; pre‐eclampsia; Retrospective Studies; small for gestational age; Thailand - epidemiology; Young Adult
• ISSN: 0020-7292; 1879-3479; 1879-3479
• DOI: 10.1002/ijgo.15912

Objective The aim of the present study was to evaluate the obstetric complications associated with isolated fetal congenital heart disease (CHD) by comparing pregnancies with and without this condition. Methods In this retrospective matched comparative study at Siriraj Hospital, Thailand, we included 233 postnatally confirmed fetal CHD cases and 466 unaffected fetuses. Controls were selected at a 2:1 ratio, ensuring that they matched the cases in terms of maternal age, parity, and history of preterm deliveries. Results Fetal CHD was significantly associated with an increased risk of spontaneous preterm labor (30% vs 9.7%; adjusted odds ratio [aOR] 2.42; 95% confidence interval [CI]: 1.35–4.36; P = 0.003), delivery before 34 gestational weeks (11.6% vs 0.6%; aOR 12.33; 95% CI: 3.32–45.78; P