Formation of angiotensin III by angiotensin-converting enzyme

Angiotensin III is formed from des-Asp1 -angiotensin I by angiotensin-converting enzyme. The Km (11 muM) of the reaction is one-third of that for the conversion of angiotensin I into angiotensin II. As suggested by the Km values, bradykinin, peptide BPP9a and angiotensins II and III are better inhib...

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Bibliographic Details
Published in:Biochemical journal 1976-04, Vol.155 (1), p.189-192
Main Authors: Chiu, A T, Ryan, J W, Stewart, J M, Dorer, F E
Format: Article
Language:English
Subjects:
Angiotensin II - analogs & derivatives
Angiotensin II - biosynthesis
Angiotensin II - metabolism
Angiotensin II - pharmacology
Angiotensin-Converting Enzyme Inhibitors
Bradykinin - pharmacology
Peptidyl-Dipeptidase A - metabolism
Saralasin - pharmacology
Spectrometry, Fluorescence
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Summary:Angiotensin III is formed from des-Asp1 -angiotensin I by angiotensin-converting enzyme. The Km (11 muM) of the reaction is one-third of that for the conversion of angiotensin I into angiotensin II. As suggested by the Km values, bradykinin, peptide BPP9a and angiotensins II and III are better inhibitors of the formation of angiotensin II than of the formation of angiotensin III.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj1550189