Anxiety in late-life depression is associated with poorer performance across multiple cognitive domains

• Published in: Journal of the International Neuropsychological Society 2024-11, Vol.30 (9), p.807-811
• Main Authors: Kryza-Lacombe, Maria, Kassel, Michelle T., Insel, Philip S., Rhodes, Emma, Bickford, David, Burns, Emily, Butters, Meryl A., Tosun, Duygu, Aisen, Paul, Raman, Rema, Saykin, Andrew J., Toga, Arthur W., Jack, Clifford R., Weiner, Michael W., Nelson, Craig, Mackin, R. Scott
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Aging; Anxiety; Anxiety - epidemiology; Brief Communication; Cognition & reasoning; Cognition Disorders - etiology; Comorbidity; Depressive Disorder, Major - complications; Depressive Disorder, Major - epidemiology; Executive function; Executive Function - physiology; Female; Generalized anxiety disorder; Humans; Language; Male; Memory; Mental depression; Neurodegenerative diseases; Neuropsychological Tests; Observational studies; Older people; Psychiatric Status Rating Scales; Psychotherapy; Semantics; Spatial memory; Variables
• ISSN: 1355-6177; 1469-7661; 1469-7661
• DOI: 10.1017/S1355617724000262

Anxiety is a common comorbid feature of late-life depression (LLD) and is associated with poorer global cognitive functioning independent of depression severity. However, little is known about whether comorbid anxiety is associated with a domain-specific pattern of cognitive dysfunction. We therefore examined group differences (LLD with and without comorbid anxiety) in cognitive functioning performance across multiple domains. Older adults with major depressive disorder ( = 228, ages 65-91) were evaluated for anxiety and depression severity, and cognitive functioning (learning, memory, language, processing speed, executive functioning, working memory, and visuospatial functioning). Ordinary least squares regression adjusting for age, sex, education, and concurrent depression severity examined anxiety group differences in performance on tests of cognitive functioning. Significant group differences emerged for confrontation naming and visuospatial functioning, as well as for verbal fluency, working memory, and inhibition with lower performance for LLD with comorbid anxiety compared to LLD only, controlling for depression severity. Performance patterns identified among older adults with LLD and comorbid anxiety resemble neuropsychological profiles typically seen in neurodegenerative diseases of aging. These findings have potential implications for etiological considerations in the interpretation of neuropsychological profiles.