Inhibition of pig kidney diamine oxidase by substrate analogues

1. The oxidation of p-dimethylaminomethylbenzylamine was followed spectrophotometrically by measuring the change in E(250) caused by the p-dimethylaminomethylbenzaldehyde produced. 2. This reaction was inhibited by substrate analogues such as isothiouronium, guanidino, dimethylsulphonium and trimeth...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical journal 1972-06, Vol.128 (2), p.253-263
Main Authors: Bardsley, W G, Ashford, J S
Format: Article
Language:English
Subjects:
Amine Oxidase (Copper-Containing) - antagonists & inhibitors
Animals
Benzaldehydes
Guanidines - pharmacology
Kidney - enzymology
Onium Compounds - pharmacology
Oxidation-Reduction
Quaternary Ammonium Compounds - pharmacology
Spectrophotometry
Swine
Thiourea
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:1. The oxidation of p-dimethylaminomethylbenzylamine was followed spectrophotometrically by measuring the change in E(250) caused by the p-dimethylaminomethylbenzaldehyde produced. 2. This reaction was inhibited by substrate analogues such as isothiouronium, guanidino, dimethylsulphonium and trimethylammonium compounds. 3. The inhibition by both mono- and bis-onium compounds has been studied and a comprehensive theory is developed to explain both the type and degree of inhibition produced.
ISSN:0264-6021
0306-3283
1470-8728
DOI:10.1042/bj1280253