Clinical measures in chronic neuropathic pain are related to the Kennedy and endocannabinoid pathways

Background Chronic neuropathic pain (CNP) is a debilitating condition, often refractory to currently available drugs. Understanding biochemical alterations in peripheral tissues such as blood will be useful for understanding underlying pathophysiological processes relating to CNP. Methods We collect...

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Bibliographic Details
Published in:European journal of clinical investigation 2025-02, Vol.55 (2), p.e14351-n/a
Main Authors: Bourke, Stephanie L., Suarez, Eva Gonzalez, Islam, Barira, Stephenson, John, Finn, David P., McHugh, Patrick C.
Format: Article
Language:English
Subjects:
2‐arachidonoylglycerol
Adult
Aged
Analgesics
Arachidonic Acids - blood
Arachidonic Acids - metabolism
biomarker
Biomarkers
Blood
Cannabinoids
Case-Control Studies
Catabolism
Choline
choline phosphotransferase
Chronic pain
Chronic Pain - genetics
Chronic Pain - metabolism
clinical neuropathic pain
endocannabinoids
Endocannabinoids - blood
Endocannabinoids - metabolism
Female
Gene expression
Genes
Glycerides - blood
Glycerides - metabolism
Humans
Lecithin
Lipid metabolism
Lipids
Male
Mass spectrometry
Mass spectroscopy
Mental depression
Metabolism
Metabolites
Middle Aged
Neuralgia
Neuralgia - genetics
Neuralgia - metabolism
Original
Pain
Phosphatidylcholine
Phosphatidylcholines - blood
Phosphatidylcholines - metabolism
Phosphotransferase
Plasma
Plasma levels
Statistical analysis
Statistical models
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Summary:Background Chronic neuropathic pain (CNP) is a debilitating condition, often refractory to currently available drugs. Understanding biochemical alterations in peripheral tissues such as blood will be useful for understanding underlying pathophysiological processes relating to CNP. Methods We collected blood from two independent cohorts of CNP and pain‐free controls (CNP n = 129/Controls n = 127) in the UK and Ireland to investigate the relationship between CNP‐associated molecular/biochemical alterations and a range of clinical and pain metric parameters. Multiple statistical comparisons were conducted on the data, with selected variables included in one or more of the intended inferential analyses (six models). Results Gene expression analysis showed that choline phosphotransferase (CHPT1) was increased (p 
ISSN:0014-2972
1365-2362
1365-2362
DOI:10.1111/eci.14351