Association between fasting blood glucose and psychotic symptoms in Chinese patients with first-episode drug-naïve major depressive disorder

Psychotic depression (PD) is a highly debilitating disorder characterized by hallucinations and/or delusions accompanied by depression. A variety of neurotransmitters, hormones and corresponding receptors in the endocrine system are involved in the onset and progression of depression, and fasting bl...

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Bibliographic Details
Published in:BMC psychiatry 2025-01, Vol.25 (1), p.49, Article 49
Main Authors: Xia, Xingzhi, Deng, Hanxu, Ren, Wei, Yang, Lin, Zhu, Yingzhao, Liu, Yaozhi, Liu, Junjun, Zhao, Xueli, Jia, Fengnan, Du, Xiangdong, Zhang, Xiangyang
Format: Article
Language:English
Subjects:
Adult
Analysis
Blood Glucose - analysis
Blood sugar
Blood sugar monitoring
China - epidemiology
Comorbidity
Depressive Disorder, Major - blood
Depressive Disorder, Major - epidemiology
East Asian People
Fasting - blood
Female
Health aspects
Humans
Major depressive disorder
Male
Middle Aged
Psychological manifestations of general diseases
Psychotic Disorders - blood
Psychotic Disorders - complications
Psychotic Disorders - epidemiology
Suicide
Young Adult
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Summary:Psychotic depression (PD) is a highly debilitating disorder characterized by hallucinations and/or delusions accompanied by depression. A variety of neurotransmitters, hormones and corresponding receptors in the endocrine system are involved in the onset and progression of depression, and fasting blood glucose (FBG) can be an important indicator for monitoring the stability of the endocrine system. The aim of this study was to investigate the relationship between FBG and PD in a Chinese population with first-episode drug-naïve (FEDN) major depressive disorder (MDD). In this study, 1718 outpatient individuals diagnosed with first-episode drug-naïve major depressive disorder (FEDN MDD) were included. The association between PD and FBG levels was identified through multivariable binary logistic regression analysis. To investigate potential non-linear relationships, a two-piecewise linear regression model was utilized. Additionally, interaction and stratified analyses were performed based on gender, educational background, marital status, presence of comorbid anxiety, and history of suicide attempt. Multivariate logistic regression analysis showed that FBG was positively associated with the risk of PD in FEDN MDD patients (OR = 1.68, 95% CI: 1.31 to 2.13; P 
ISSN:1471-244X
1471-244X
DOI:10.1186/s12888-025-06502-2