Histopathological Evaluation of Human Placental Extract as a Direct Pulp-Capping Material in Dogs' Teeth

The current research aimed to evaluate the histopathological pulpal alterations in dogs' teeth following direct pulp capping using either mineral trioxide aggregate (MTA) or human placenta extract (HPE).  Forty-eight incisors with mature apices from four dogs were involved. The teeth were rando...

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Published in:European journal of dentistry 2025-02, Vol.19 (1), p.144-153
Main Authors: Safy, Rehab Khalil, Ragab, Mai Hamdy, Abdel-Maksoud, Heba Bahgat
Format: Article
Language:English
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Summary:The current research aimed to evaluate the histopathological pulpal alterations in dogs' teeth following direct pulp capping using either mineral trioxide aggregate (MTA) or human placenta extract (HPE).  Forty-eight incisors with mature apices from four dogs were involved. The teeth were randomly allocated to three groups (  = 16) based on the material utilized for direct pulp capping: MTA, HPE, and Teflon as the negative control group. All involved teeth were capped and restored at the same session. Each group was subsequently divided into two subgroups (  = 8) based on the post treatment evaluation period: 2 and 4 weeks. The histopathologic changes in each specimen's pulp tissues, including pulp inflammation, hyperemia, necrosis, and dentin bridge development, were assessed. Then, all the data were statistically analyzed using chi-square, -test, and one-way analysis of variance (  
ISSN:1305-7456
1305-7464
DOI:10.1055/s-0044-1786841