Bone collagen metabolism in vitamin D deficiency

Radioisotope studies have shown that collagen synthesized in the shafts of bones from rachitic rats and chicks is similar in chain composition to that normally synthesized. However, the extent of lysine hydroxylation in both alpha1- and alpha2-chains is increased, by approx. 15-30% in the rat and by...

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Bibliographic Details
Published in:Biochemical journal 1973-01, Vol.132 (1), p.113-115
Main Authors: Barnes, M J, Constable, B J, Morton, L F, Kodicek, E
Format: Article
Language:English
Subjects:
Animals
Biosynthesis and Degradation
Bone and Bones - analysis
Bone and Bones - metabolism
Chickens
Cholecalciferol - metabolism
Chromatography, Ion Exchange
Collagen - analysis
Collagen - metabolism
Hydroxylation
Hydroxylysine - analysis
Lysine - metabolism
Peptides - analysis
Rats
Time Factors
Tritium
Vitamin D Deficiency - metabolism
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Summary:Radioisotope studies have shown that collagen synthesized in the shafts of bones from rachitic rats and chicks is similar in chain composition to that normally synthesized. However, the extent of lysine hydroxylation in both alpha1- and alpha2-chains is increased, by approx. 15-30% in the rat and by 50% in the chick.
ISSN:0264-6021
0306-3283
1470-8728
DOI:10.1042/bj1320113