Difference of clinical characteristics in patients with reinfection and primary infection variants of SARS-CoV-2: a retrospective study in China

The number of patients experiencing re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is progressively increasing. In this study, we aimed to explore the differences in clinical characteristics between patients with primary infection and those with re-infection of SARS-C...

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Bibliographic Details
Published in:BMC infectious diseases 2025-02, Vol.25 (1), p.173
Main Authors: Qiu, Chao-Chao, Lin, Xiao-Qing, Zhang, Qiang, Chen, Ya-Long, Su, Xiao-Qiao, Zhang, Ming-Ying, Zhu, Le-Fei, Lin, Zhi-Ruo, Cheng, Fang, Xie, Shang-Ren, Shi, Ji-Chan, Jiang, Xian-Gao
Format: Article
Language:English
Subjects:
Adult
Aged
Care and treatment
China - epidemiology
Coronaviruses
Cough - virology
COVID-19 - complications
COVID-19 - epidemiology
COVID-19 - virology
Female
Fever - virology
Hospitalization
Humans
Information management
Male
Medical research
Medicine, Experimental
Middle Aged
Reinfection - epidemiology
Reinfection - virology
Retrospective Studies
SARS-CoV-2 - genetics
Severe acute respiratory syndrome
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Summary:The number of patients experiencing re-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is progressively increasing. In this study, we aimed to explore the differences in clinical characteristics between patients with primary infection and those with re-infection of SARS-CoV-2. A retrospective data analysis was conducted involving patients diagnosed with coronavirus disease 2019 between April 1, 2023, and June 20, 2023. The patients were categorized into two groups: the observation group, consisting of individuals re-infected with SARS-CoV-2, and the control group, comprising those with primary SARS-CoV-2 infection. A total of 905 (905/1025) patients were included in the study, with 407 in the observation group and 498 in the control group. The top three clinical symptoms in both groups were fever, cough with expectoration, and dizziness with fatigue (p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-025-10509-1