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Macrophage scavenger receptors, such as CD36 and class A scavenger receptor (SR-A), have previously been thought to play a central role in foam cell formation and atherogenesis by mediating the uptake of oxidized LDL. In this issue of the JCI, Moore et al. report that Apoe mice deficient in either C...

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Bibliographic Details
Published in:The Journal of clinical investigation 2005-08, Vol.115 (8), p.2072-2075
Main Author: Witztum, Joseph L
Format: Article
Language:English
Subjects:
Animals
Aortic Valve - metabolism
Apolipoproteins E - genetics
Apolipoproteins E - metabolism
Arteriosclerosis - genetics
Arteriosclerosis - metabolism
Biomedical research
CD36 Antigens - genetics
CD36 Antigens - metabolism
Foam Cells - metabolism
Gene Deletion
Humans
Lipoproteins, LDL - metabolism
Mice
Mice, Knockout
Receptors, Immunologic - genetics
Receptors, Immunologic - metabolism
Receptors, Scavenger
Scavenger Receptors, Class A
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Summary:Macrophage scavenger receptors, such as CD36 and class A scavenger receptor (SR-A), have previously been thought to play a central role in foam cell formation and atherogenesis by mediating the uptake of oxidized LDL. In this issue of the JCI, Moore et al. report that Apoe mice deficient in either CD36 or SR-A did not have less atherosclerosis at the level of the aortic valve than did wild-type Apoe mice. In contrast, similar studies by previous investigators found that deletion of these receptors decreased atherogenesis. The reasons for the different results are not known, but these data suggest that the role of these receptors in atherogenesis remains unresolved.
ISSN:0021-9738
1558-8238
DOI:10.1172/JCI26130