Genomewide Scan for Gout in Taiwanese Aborigines Reveals Linkage to Chromosome 4q25

• Published in: American journal of human genetics 2004-09, Vol.75 (3), p.498-503
• Main Authors: Shu-Chuan Cheng, Li, Chiang, Shang-Lun, Tu, Hung-Pin, Chang, Shun-Jen, Wang, Tsu-Nai, Ko, Allen Min-Jen, Chakraborty, Ranajit, Ko, Ying-Chin
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Chromosomes, Human, Pair 4; Classical genetics, quantitative genetics, hybrids; Family Health; Founder Effect; Fundamental and applied biological sciences. Psychology; General aspects. Genetic counseling; Genetic Linkage; Genetic Markers; Genetic Predisposition to Disease; Genetics of eukaryotes. Biological and molecular evolution; Genome, Human; Gout - genetics; Human; Humans; Hyperuricemia - genetics; Lod Score; Medical genetics; Medical sciences; Metabolic diseases; Middle Aged; Models, Genetic; Other metabolic disorders; Pedigree; Polymorphism, Genetic; Purines and pyrimidines (gout, hyperuricemia...); Quantitative Trait, Heritable; Taiwan
• ISSN: 0002-9297; 1537-6605
• DOI: 10.1086/423429

Gout is a disorder of uric-acid metabolism. The Pacific Austronesian population, including Taiwanese aborigines, has a remarkably high prevalence of hyperuricemia and gout, which suggests a founder effect across the Pacific region. We report here a genomewide linkage study of 21 multiplex pedigrees with gout from an aboriginal tribe in Taiwan. From observations of familial clustering, early onset of gout, and clinically severe manifestations, we hypothesized that a major gene plays a role in this trait. Using 382 random polymorphic markers spread across 22 autosomes, we demonstrated a highly significant linkage for gout at marker D4S2623 on chromosome 4q25 ( P=.0002 by nonparametric linkage [the NPL all statistic]; empirical P=.0006; LOD=4.3, P=4.4×10 −6 by logistic regression). When alcohol consumption was included as a covariate in the model, the LOD score increased to 5.66 ( P=1.3×10 −6). Quantitative traits, including serum uric acid and creatinine, also showed a moderate linkage to this region. To our knowledge, this is the first genome-scan report to identify a genetic locus harboring a gout-susceptibility gene.