Finding groups in gene expression data

The vast potential of the genomic insight offered by microarray technologies has led to their widespread use since they were introduced a decade ago. Application areas include gene function discovery, disease diagnosis, and inferring regulatory networks. Microarray experiments enable large-scale, hi...

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Bibliographic Details
Published in:BioMed research international 2005-06, Vol.2005 (2), p.215-225
Main Authors: Hand, David J, Heard, Nicholas A
Format: Article
Language:English
Subjects:
Gene expression
Genetic research
Medical research
Medicine, Experimental
Methodology
Methods
Review
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Summary:The vast potential of the genomic insight offered by microarray technologies has led to their widespread use since they were introduced a decade ago. Application areas include gene function discovery, disease diagnosis, and inferring regulatory networks. Microarray experiments enable large-scale, high-throughput investigations of gene activity and have thus provided the data analyst with a distinctive, high-dimensional field of study. Many questions in this field relate to finding subgroups of data profiles which are very similar. A popular type of exploratory tool for finding subgroups is cluster analysis, and many different flavors of algorithms have been used and indeed tailored for microarray data. Cluster analysis, however, implies a partitioning of the entire data set, and this does not always match the objective. Sometimes pattern discovery or bump hunting tools are more appropriate. This paper reviews these various tools for finding interesting subgroups.
ISSN:1110-7243
2314-6133
2314-6141
DOI:10.1155/jbb.2005.215