Phosphorylation of additional sites on pyruvate dehydrogenase inhibits its re-activation by pyruvate dehydrogenase phosphate phosphatase

The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.

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Bibliographic Details
Published in:Biochemical journal 1978-02, Vol.169 (2), p.433-435
Main Authors: Sugden, P H, Hutson, N J, Kerbey, A L, Randle, P J
Format: Article
Language:English
Subjects:
Animals
Binding Sites
Kinetics
Myocardium - enzymology
Phosphates - metabolism
Phosphoproteins - metabolism
Phosphoric Monoester Hydrolases - metabolism
Pyruvate Dehydrogenase (Lipoamide)-Phosphatase - metabolism
Pyruvate Dehydrogenase Complex - antagonists & inhibitors
Swine
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Description
Summary:The phosphorylation of sites additional to an inactivating site inhibits the formation of active pig heart pyruvate dehydrogenase complex from inactive pyruvate dehydrogenase phosphate complex by pig heart pyruvate dehydrogenase phosphate phosphatase.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj1690433