Blood-group-I activity associated with band 3, the major intrinsic membrane protein of human erythrocytes

Affinity chromatography of radioiodinated solubilized erythrocyte stroma and of radioiodinated purified Band 3 on an anti-(blood-group I)-adsorbent column showed blood-group-I activity associated with a subpopulation of Band 3. The specificity of binding was confirmed by inhibition with known blood-...

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Bibliographic Details
Published in:Biochemical journal 1978-07, Vol.173 (1), p.333-336
Main Authors: Childs, R A, Feizi, T, Fukuda, M, Hakomori, S I
Format: Article
Language:English
Subjects:
Blood Group Antigens
Chromatography, Affinity
Electrophoresis, Polyacrylamide Gel
Erythrocyte Membrane - immunology
Erythrocytes - immunology
Humans
I Blood-Group System
Membrane Proteins - immunology
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Summary:Affinity chromatography of radioiodinated solubilized erythrocyte stroma and of radioiodinated purified Band 3 on an anti-(blood-group I)-adsorbent column showed blood-group-I activity associated with a subpopulation of Band 3. The specificity of binding was confirmed by inhibition with known blood-group substances in radioimmunoassays.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj1730333