L-proline transport by newborn rat kidney brush-border membrane vesicles

The transport of L-proline was studied in brush-border membrane vesicles isolated from the kidneys of newborn rats. In contrast with the rapid initial uptake with an 'overshoot' observed in adult vesicles, uptake by the newborn vesicle was slow, showed no 'overshoot', and proline...

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Bibliographic Details
Published in:Biochemical journal 1979-01, Vol.178 (1), p.253-256
Main Authors: Goldmann, D R, Roth, K S, Langfitt, Jr, T W, Segal, S
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn - metabolism
Biological Transport
In Vitro Techniques
Kidney Cortex - metabolism
Microvilli - metabolism
Proline - metabolism
Rats
Sodium - metabolism
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Summary:The transport of L-proline was studied in brush-border membrane vesicles isolated from the kidneys of newborn rats. In contrast with the rapid initial uptake with an 'overshoot' observed in adult vesicles, uptake by the newborn vesicle was slow, showed no 'overshoot', and proline continued to accumulate at a time when the adult vesicle had already equilibrated. L-Proline transport in the newborn rat occurs by Na+-dependent and independent mechanisms. There appeared to be essentially no uptake by anti-luminal vesicles isolated from newborn rat kidney. These observations may help to explain the prolinuria that occurs in the newborn animal.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj1780253