Effects of carbon tetrachloride on isolated rat hepatocytes. Inhibition of protein and lipoprotein secretion

The effects of carbon tetrachloride on protein and lipoprotein secretion, and on lipid peroxidation, have been investigated in isolated rat hepatocytes. It was found that although the free-radical scavenger promethazine completely suppressed the increased peroxidation produced by carbon tetrachlorid...

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Bibliographic Details
Published in:Biochemical journal 1979-02, Vol.178 (2), p.509-512
Main Authors: Gravela, E, Albano, E, Dianzani, M U, Poli, G, Slater, T F
Format: Article
Language:English
Subjects:
Animals
Carbon Tetrachloride - pharmacology
In Vitro Techniques
Lipoproteins - metabolism
Liver - cytology
Liver - drug effects
Liver - metabolism
Peroxides
Proteins - metabolism
Rats
Secretory Rate - drug effects
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Summary:The effects of carbon tetrachloride on protein and lipoprotein secretion, and on lipid peroxidation, have been investigated in isolated rat hepatocytes. It was found that although the free-radical scavenger promethazine completely suppressed the increased peroxidation produced by carbon tetrachloride, it had no effect on the inhibitory action of carbon tetrachloride on lipoprotein secretion. In consequence, the latter effect of carbon tetrachloride does not appear to be mediated through a peroxidative stage.
ISSN:0264-6021
0306-3283
1470-8728
DOI:10.1042/bj1780509