IGFs and IGFBPs: surrogate markers for diagnosis and surveillance of tumour growth?

Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysr...

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Bibliographic Details
Published in:Molecular pathology 2001-10, Vol.54 (5), p.285-288
Main Author: Zumkeller, W
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomarkers, Tumor - blood
Breast Neoplasms - metabolism
Cancer
Carrier proteins
Colorectal Neoplasms - metabolism
Female
Host-tumor relations. Immunology. Biological markers
Humans
insulin-like growth factor binding proteins
Insulin-Like Growth Factor Binding Proteins - blood
Insulin-Like Growth Factor I - analysis
Insulin-Like Growth Factor II - analysis
Insulin-like growth factors
Male
Medical sciences
Mice
Mice, Transgenic
Molecular biology
Physiological aspects
Prostatic Neoplasms - metabolism
Rats
Receptor, IGF Type 1 - blood
Receptor, IGF Type 2 - blood
Review
Tumor markers
Tumors
tumour marker
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Summary:Insulin-like growth factors (IGFs), IGF receptors, and IGF binding proteins (IGFBPs) constitute the IGF system. Comprehensive data indicate that these factors play a pivotal role in tumorigenesis. Epidemiological data indicate that cancer risk is associated with high serum IGF-I values. Because dysregulation of the IGF system is a frequent pattern in malignancy, IGFs/IGFBPs might represent novel tumour markers that could be useful both for diagnosis and surveillance.
ISSN:1366-8714
1472-4154
DOI:10.1136/mp.54.5.285