The effect of yohimbine, an alpha2 adrenergic receptor antagonist, on the growth hormone response to apomorphine in normal subjects

Yohimbine HCl (16 mg po) administered 30 min before clonidine (CLON) (2 ug/kg infused over 10 min) (N = 5) or apomorphine HCl (Apo) (0.5 mg sc) (N = 10) antagonized the growth hormone (GH) response to CLON but had no effect on the GH response to Apo in normal men. This finding suggests that in human...

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Bibliographic Details
Published in:Journal of psychiatry & neuroscience 1996-03, Vol.21 (2), p.96-100
Main Authors: LAL, S, THAVUNDAYIL, J. X, KRISHNAN, B, NAIR, N. P. V, SCHWARTZ, G, GUYDA, H
Format: Article
Language:English
Subjects:
Adrenergic alpha-Antagonists - pharmacology
Adult
Apomorphine - metabolism
Biological and medical sciences
Clonidine - metabolism
Dopamine Agonists - metabolism
Fundamental and applied biological sciences. Psychology
Growth Hormone - metabolism
Hormones and neuropeptides. Regulation
Humans
Hypothalamo-Hypophyseal System - drug effects
Hypothalamus. Hypophysis. Epiphysis. Urophysis
Male
Pituitary-Adrenal System - drug effects
Placebos
Vertebrates: endocrinology
Yohimbine - pharmacology
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Summary:Yohimbine HCl (16 mg po) administered 30 min before clonidine (CLON) (2 ug/kg infused over 10 min) (N = 5) or apomorphine HCl (Apo) (0.5 mg sc) (N = 10) antagonized the growth hormone (GH) response to CLON but had no effect on the GH response to Apo in normal men. This finding suggests that in humans, alpha2 adrenergic mechanisms do not modulate dopaminergic function, at least not in the hypothalamic-pituitary axis, and that the GH response to Apo is not mediated via an alpha2 adrenergic link.
ISSN:1180-4882
1488-2434