Platelet abnormalities in aggressive subjects with mental deficiency

Platelet 3H-imipramine (3H-IMI) binding and platelet sulfotransferase (ST) activity, taken as markers of the serotonin (5-HT) and sulfated neurotransmitters (tyramine, dopamine, serotonin, noradrenaline), respectively, were evaluated in 14 severely aggressive subjects institutionalized since childho...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychiatry & neuroscience 1996-03, Vol.21 (2), p.109-113
Main Authors: MARAZZITI, D, PALEGO, L, SILVESTRI, S, PRESTA, S, BALESTRI, C, BATISTINI, A, CONTI, L
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aggression
Antidepressive Agents - blood
Binding Sites
Biological and medical sciences
Dopamine - blood
Female
Humans
Imipramine - blood
Intellectual deficiency
Intellectual Disability - blood
Male
Medical sciences
Neurotransmitter Agents - blood
Platelet Count
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Serotonin - blood
Sulfotransferases - blood
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Platelet 3H-imipramine (3H-IMI) binding and platelet sulfotransferase (ST) activity, taken as markers of the serotonin (5-HT) and sulfated neurotransmitters (tyramine, dopamine, serotonin, noradrenaline), respectively, were evaluated in 14 severely aggressive subjects institutionalized since childhood for mental retardation and in an equal number of healthy controls. The results showed the presence of a lower number of 3H-IMI binding sites and a higher ST activity in the patients as compared with controls. These data provide supporting evidence for the hypothesis of an abnormality of the 5-HT system and suggest possible dysfunctions of dopamine and sulfated amines in aggressive behavior, at least as reflected by platelet markers.
ISSN:1180-4882
1488-2434