Rate of decline in cortisol concentrations in ovarian follicles following ACTH treatment in the sow

The rates of decline in cortisol concentrations in blood and ovarian follicular fluid were assessed in cyclic sows (n = 30) after treatment with saline or a depot form of adrenocorticotrophic hormone (ACTH). After a single injection of ACTH (0.5 iu/kg, BW, i.m.), peak cortisol values were achieved i...

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Bibliographic Details
Published in:Canadian journal of veterinary research 1997-10, Vol.61 (4), p.309-311
Main Authors: Montgomery, A, Viveiros, M, Cummings, E, Liptrap, R
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - pharmacology
Animals
blood serum
corticotropin
cortisol
Dose-Response Relationship, Drug
Estrus - physiology
Female
follicular fluid
Follicular Fluid - chemistry
Half-Life
Hydrocortisone - analysis
Hydrocortisone - blood
Hydrocortisone - metabolism
Injections, Intramuscular - methods
Injections, Intramuscular - veterinary
Ovarian Follicle - chemistry
Ovarian Follicle - drug effects
Ovarian Follicle - metabolism
ovarian follicles
persistence
pituitary-gonadal axis
sows
stress response
Swine - metabolism
Swine - physiology
Time Factors
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Summary:The rates of decline in cortisol concentrations in blood and ovarian follicular fluid were assessed in cyclic sows (n = 30) after treatment with saline or a depot form of adrenocorticotrophic hormone (ACTH). After a single injection of ACTH (0.5 iu/kg, BW, i.m.), peak cortisol values were achieved in blood within 3 to 4 h followed by a half-life net clearance rate (t1/2 of 2.40 +/- 0.29 (SE) h. The same dose of ACTH was then given at 12 h intervals from days 9 to 13 of the estrous cycle. On day 14 the concentrations of cortisol in follicular fluid were higher (P < 0.05) in ACTH-injected sows than in saline-injected controls. A t1/2 value of 37.81 h was determined for cortisol based on the decline in concentrations in follicular fluid collected on days 14, 16 and 18. This relatively slow rate of removal from developing ovarian follicles may have implications for the previously observed detrimental effects of increased cortisol concentrations on follicular development.
ISSN:0830-9000