Nerve-mediated contractions of sheep mesenteric lymph node capsules

1. Isometric tension was recorded in vitro from strips cut from the capsules of mesenteric lymph nodes of sheep. 2. One minute periods of field stimulation at frequencies of 1, 2, 4, 8 and 16 Hz (pulse duration, 0.3 ms) elicited tonic contractions of increasing force and duration. The stimulus frequ...

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Bibliographic Details
Published in:The Journal of physiology 1990-03, Vol.422 (1), p.513-522
Main Authors: Thornbury, K D, McHale, N G, Allen, J M, Hughes, G
Format: Article
Language:English
Subjects:
Adrenergic alpha-Antagonists - pharmacology
Animals
Atropine - pharmacology
Biological and medical sciences
Desipramine - pharmacology
Fundamental and applied biological sciences. Psychology
In Vitro Techniques
Isometric Contraction - drug effects
Isometric Contraction - physiology
Lymph Nodes - innervation
Lymph Nodes - physiology
Lymphatic system
Muscle Contraction - physiology
Muscle, Smooth - physiology
Sheep
Tetrodotoxin - pharmacology
Time Factors
Vertebrates: cardiovascular system
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Summary:1. Isometric tension was recorded in vitro from strips cut from the capsules of mesenteric lymph nodes of sheep. 2. One minute periods of field stimulation at frequencies of 1, 2, 4, 8 and 16 Hz (pulse duration, 0.3 ms) elicited tonic contractions of increasing force and duration. The stimulus frequency-response relationship began to flatten out at frequencies greater than 4 Hz, where the response was already 72% of that at 16 Hz. 3. The response to field stimulation was abolished by tetrodotoxin (1 microM). 4. Phentolamine, rauwolscine and prazosin (all 1 microM) reduced the response to field stimulation, while desipramine (1 microM), potentiated it. 5. Atropine (1 microM) was without effect on the response. 6. These results suggest that sheep mesenteric lymph node capsules have a noradrenergic innervation which modulates their tone via an action on alpha-adrenoceptors.
ISSN:0022-3751
1469-7793
DOI:10.1113/jphysiol.1990.sp017998