Laparoscopic surgery and the systemic immune response

The authors review studies relating to the immune responses evoked by laparoscopic surgery. Laparoscopic surgery has gained rapid acceptance based on clinical grounds. Patients benefit from faster recovery, decreased pain, and quicker return to normal activities. Only more recently have attempts bee...

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Bibliographic Details
Published in:Annals of surgery 1998-03, Vol.227 (3), p.326-334
Main Authors: VITTIMBERGA, F. J, FOLEY, D. P, MEYERS, W. C, CALLERY, M. P
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carbon Dioxide - pharmacology
Humans
Immunity - drug effects
Interleukin-6 - biosynthesis
Laparoscopy
Leukocyte Count
Macrophage Activation
Medical sciences
Miscellaneous
Neoplasms - immunology
Neoplasms - pathology
Peritoneum - immunology
Pneumoperitoneum, Artificial
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
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Summary:The authors review studies relating to the immune responses evoked by laparoscopic surgery. Laparoscopic surgery has gained rapid acceptance based on clinical grounds. Patients benefit from faster recovery, decreased pain, and quicker return to normal activities. Only more recently have attempts been made to identify the metabolic and immune responses that may underlie this clinical success. The immune responses to laparoscopy are now being evaluated in relation to the present knowledge of immune responses to traditional laparotomy and surgery in general. A review of the published literature of the immune and metabolic responses to laparoscopy was performed. Laparoscopic surgery is compared with the traditional laparotomy on the basis of local and systemic immune responses and patterns of tumor growth. The impact of pneumoperitoneum and insufflation gases on the immune response is also reviewed. The systemic immune responses for surgery in general may not apply to laparoscopic surgery. The body's response to laparoscopy is one of lesser immune activation as opposed to immunosuppression.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-199803000-00003