Prognostic value of platelet-derived growth factor-A (PDGF-A) in gastric carcinoma

Because our previous study indicated that PDGF-A mRNA expression in biopsy specimens might identify a subgroup of high-risk patients with gastric carcinoma, in this study we analyzed the prognostic value of platelet-derived growth factor-A (PDGF-A) gene expression in gastric carcinoma biopsy specime...

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Bibliographic Details
Published in:Annals of surgery 1998-03, Vol.227 (3), p.365-371
Main Authors: KATANO, M, NAKAMURA, M, FUJIMOTO, K, MIYAZAKI, K, MORISAKI, T
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Biological and medical sciences
Biomarkers, Tumor - analysis
Digestive system
Female
Follow-Up Studies
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Multivariate Analysis
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Platelet-Derived Growth Factor - analysis
Platelet-Derived Growth Factor - genetics
Prognosis
RNA, Messenger - analysis
Stomach Neoplasms - chemistry
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Summary:Because our previous study indicated that PDGF-A mRNA expression in biopsy specimens might identify a subgroup of high-risk patients with gastric carcinoma, in this study we analyzed the prognostic value of platelet-derived growth factor-A (PDGF-A) gene expression in gastric carcinoma biopsy specimens. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to analyze the PDGF-A gene expression in 65 gastric carcinoma endoscopic biopsy specimens. The 65 patients were divided into a PDGF-A-positive group (29 patients) and a PDGF-A-negative group (36 patients). On the basis of 2-year follow-up data, the PDGF-A-positive group demonstrated a shorter overall survival rate compared with the PDGF-A-negative group (p < 0.0001). A similar correlation was found in 34 advanced-stage patients (p = 0.003) and in 24 advanced-stage patients who underwent a curative resection (p = 0.003). Multivariance analysis indicated that the transcription of PDGF-A gene is a potent prognostic factor that is independent of the traditional pathologic parameters. Expression of PDGF-A mRNA in gastric biopsy specimens may be a new preoperative prognostic parameter in gastric carcinoma.
ISSN:0003-4932
1528-1140
DOI:10.1097/00000658-199803000-00008