Verrucous carcinoma of the anus containing human papillomavirus type 16 DNA detected by in situ hybridisation : a case report

Verrucous carcinoma of the anus is a distinct and rare variant of well-differentiated squamous cell carcinoma. A case of anal verrucous carcinoma in a 35 year old man was studied by light microscopy and in situ DNA hybridization. Human papillomavirus (HPV) type 16 DNA sequences were demonstrated in...

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Bibliographic Details
Published in:Genitourinary medicine 1990-10, Vol.66 (5), p.342-345
Main Authors: FUJU CHANG, KOSUNEN, O, KOSMA, V.-M, SYRJÄNEN, S, LAHTINEN, J, SYRJÄNEN, K
Format: Article
Language:English
Subjects:
Adult
Anus Neoplasms - genetics
Biological and medical sciences
Carcinoma, Papillary - genetics
DNA, Neoplasm - analysis
Epithelium - microbiology
Gynecology. Andrology. Obstetrics
Humans
Male
Male genital diseases
Medical sciences
Molecular Probe Techniques
Non tumoral diseases
Nucleic Acid Hybridization
Papillomaviridae - genetics
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Summary:Verrucous carcinoma of the anus is a distinct and rare variant of well-differentiated squamous cell carcinoma. A case of anal verrucous carcinoma in a 35 year old man was studied by light microscopy and in situ DNA hybridization. Human papillomavirus (HPV) type 16 DNA sequences were demonstrated in the tumour cells, as well as in cells showing koilocytotic and dyskeratotic changes. The possible viral (HPV) aetiology of verrucous carcinoma is considered with a review of the previous literature.
ISSN:0266-4348
1368-4973
DOI:10.1136/sti.66.5.342