Secretin and sleep in children with autism

The objectives of this pilot study were 1) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism, and 2) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism. Participants were a subset of subjects...

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Bibliographic Details
Published in:Child psychiatry and human development 2002-01, Vol.33 (2), p.107-123
Main Authors: Honomichl, Ryan D, Goodlin-Jones, Beth L, Burnham, Melissa M, Hansen, Robin L, Anders, Thomas F
Format: Article
Language:English
Subjects:
Autism
Autistic children
Autistic Disorder - complications
Child
Child, Preschool
Children & youth
Cross-Over Studies
Double-Blind Method
Gastrointestinal Agents - therapeutic use
Hormones
Humans
Infusions, Intravenous
Multivariate Analysis
Pilot Projects
Pilot studies
Polysomnography - methods
Secretin - therapeutic use
Sleep
Sleep Wake Disorders - drug therapy
Sleep Wake Disorders - etiology
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Summary:The objectives of this pilot study were 1) to examine possible effects of secretin infusions on sleep-wake state organization in children with autism, and 2) to assess the feasibility of home recordings using time-lapse videosomnography in children with autism. Participants were a subset of subjects from two double blind, placebo-control, multi-center clinical trials. One trial, the UC Irvine study, assessed the effects of porcine secretin vs. saline infusions on children's behavior, language and IQ. The UC Davis trial assessed the effects of synthetic human secretin vs. saline infusions on behavior, language and gastrointestinal function. The sleep study enrolled some of the children from each of the two trials to observe possible secretin effects on sleep. To examine sleep, the UC Irvine trial used the Children's Sleep Habits Questionnaire and daily sleep diaries, whereas the UC Davis study used home-recorded time-lapse videosomnography. Because of the small sample size, the results from both trials are preliminary. They suggest that secretin, porcine or synthetic, does not improve sleep-wake state organization dramatically.
ISSN:0009-398X
1573-3327
DOI:10.1023/A:1020778108068