Molecular Evolution of the Escherichia coli Chromosome. II. Clonal Segments

Remarkable sequence similarities in the trp region among Escherichia coli strains of diverse natural origins imply the existence of worldwide clones of very recent origin. This in turn implies a low rate of fixation of new universally favorable alleles, which carry adjacent stretches of chromosome t...

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Bibliographic Details
Published in:Genetics (Austin) 1988-10, Vol.120 (2), p.359-366
Main Authors: Milkman, R, Stoltzfus, A
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biological Evolution
Chromosomes, Bacterial
Cloning, Molecular
Escherichia coli - genetics
Escherichia coli - ultrastructure
Fundamental and applied biological sciences. Psychology
Genetics of eukaryotes. Biological and molecular evolution
Investigations
Mutation
Polymorphism, Genetic
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Summary:Remarkable sequence similarities in the trp region among Escherichia coli strains of diverse natural origins imply the existence of worldwide clones of very recent origin. This in turn implies a low rate of fixation of new universally favorable alleles, which carry adjacent stretches of chromosome to high frequency. These clonal segments begin as entire chromosomes; recombination shortens them progressively by substituting less closely related homologous DNA. The rate of this recombination, comprising the introduction of a homologous chromosomal fragment to a cell and the replacement of part of the original chromosome, is estimated from observations.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/120.2.359