Sequence Amplification and Gene Rearrangement in Parasitic Nematode Mitochondrial DNA

The nematode Romanomermis culicivorax, an obligate mosquito parasite, possesses a 26 kilobase (kb) mitochondrial genome. The unusually large size is due to transcriptionally active DNA sequences present as 3.0 kb direct tandem repeats and as inverted portions of the repeating unit located elsewhere...

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Bibliographic Details
Published in:Genetics (Austin) 1988-11, Vol.120 (3), p.707-712
Main Authors: Hyman, B. C, Beck, J. L, Weiss, K. C
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Densitometry
DNA, Mitochondrial - genetics
Electron Transport Complex IV - genetics
Fundamental and applied biological sciences. Psychology
Gene Rearrangement
Genes. Genome
Genetic Linkage
Investigations
Mermithoidea - enzymology
Mermithoidea - genetics
Molecular and cellular biology
Molecular genetics
Nucleic Acid Hybridization
Repetitive Sequences, Nucleic Acid
Restriction Mapping
Romanomermis culicivorax
Transcription, Genetic
Citations: Items that cite this one
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Summary:The nematode Romanomermis culicivorax, an obligate mosquito parasite, possesses a 26 kilobase (kb) mitochondrial genome. The unusually large size is due to transcriptionally active DNA sequences present as 3.0 kb direct tandem repeats and as inverted portions of the repeating unit located elsewhere in the mitochondrial DNA (mtDNA). The genome rearrangements involved in establishing this unusual sequence organization may have dramatically altered conventional mitochondrial gene order. Genes for subunits of the cytochrome c oxidase complex (COI and COII) are normally closely linked in animal mtDNAs, but are separated by approximately 8 kb in this mitochondrial genome.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/120.3.707