Phenotypic and genetic analysis of Clock, a new circadian rhythm mutant in Drosophila melanogaster

Clock is a semidominant X-linked mutation that results in shortening the period of Drosophila melanogaster's free-running locomotor activity rhythm from ca. 24.0 to ca. 22.5 hr. This mutation similarly shortened the phase response curve, determined by resetting activity rhythms with light pulse...

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Bibliographic Details
Published in:Genetics (Austin) 1990-07, Vol.125 (3), p.557-578
Main Authors: Dushay, M.S. (Brandeis University, Waltham, MA), Konopka, R.J, Orr, D, Greenacre, M.L, Kyriacou, C.P, Rosbash, M, Hall, J.C
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
CHROMOSOME
Chromosome Aberrations
Chromosome Mapping
Circadian Rhythm
Classical genetics, quantitative genetics, hybrids
COMPORTAMIENTO SEXUAL
COMPORTEMENT SEXUEL
CROMOSOMAS
Diptera
DROSOPHILA
Drosophila melanogaster - genetics
Drosophila melanogaster - physiology
Drosophilidae
FENOTIPOS
Fundamental and applied biological sciences. Psychology
GENE
GENES
GENETICA
Genetics of eukaryotes. Biological and molecular evolution
GENETIQUE
Invertebrata
Investigations
LOCOMOCION
LOCOMOTION
Motor Activity
MUTACION
MUTANT
MUTANTES
MUTATION
PHENOTYPE
POLIMORFISMO
POLYMORPHISME
RECOMBINACION
RECOMBINAISON
Recombination, Genetic
RITMOS BIOLOGICOS
RYTHME BIOLOGIQUE
SEXE
SEXO
Temperature
Time Factors
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Summary:Clock is a semidominant X-linked mutation that results in shortening the period of Drosophila melanogaster's free-running locomotor activity rhythm from ca. 24.0 to ca. 22.5 hr. This mutation similarly shortened the phase response curve, determined by resetting activity rhythms with light pulses. Eclosion peaks for Clk cultures were separated by only 22.5 hr instead of the normal 24 hr. Clk was mapped close to, but separable from, another rhythm mutation--period(01)--by recombination. The estimated distance between these two mutations was short enough to suggest that Clk could be a per allele. If this is the case, the new mutant is unique in that it, unlike other per variants, is associated with essentially normal 1-min courtship song rhythms when Clk is expressed in males. Also, the new rhythm variant could not, in contrast to a short-period per mutation, have its effects on free-running activity rhythms uncovered by deletions. This result, and the lack of coverage of Clk's effects by duplications, suggest that it is not a simple hypomorphic or amorphic mutation
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/125.3.557