Two-Locus Linkage Analysis Using Recombinant Inbred Strains and Bayes' Theorem

Recombinant inbred (RI) strains are useful in linkage analysis and gene mapping. The currently available statistical tests of linkage using data derived from the study of RI strains, including a previous Bayesian analysis, have not been stringent enough guides for conclusions about linkage. In this...

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Bibliographic Details
Published in:Genetics (Austin) 1990-09, Vol.126 (1), p.277-284
Main Author: Neumann, P. E
Format: Article
Language:English
Subjects:
Animals
Bayes Theorem
Biological and medical sciences
Chromosomes
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Genetic Linkage
Genetic Markers
Genetics of eukaryotes. Biological and molecular evolution
Investigations
Methods, theories and miscellaneous
Models, Genetic
Recombination, Genetic
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Summary:Recombinant inbred (RI) strains are useful in linkage analysis and gene mapping. The currently available statistical tests of linkage using data derived from the study of RI strains, including a previous Bayesian analysis, have not been stringent enough guides for conclusions about linkage. In this paper, the probability of linkage was estimated using Bayes' theorem. Tables are presented that give the probability of linkage in sets of up to 30 RI strains and the critical values of i (the number of recombinants) in sets of up to 100 RI strains. Several means of increasing the power of RI strains in linkage analysis are discussed.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/126.1.277