Genetics of 51D-52A, a region containing several maternal-effect genes and two maternal-specific transcripts in Drosophila

Two genomic clones exhibiting a maternal-specific pattern of expression map to cytological region 52A. To elucidate the function of these clones we have undertaken a mutagenesis of the cytological region 51D-52A. This paper presents the results of this screen and the preliminary analysis of female-s...

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Bibliographic Details
Published in:Genetics (Austin) 1990-11, Vol.126 (3), p.639-650
Main Authors: Underwood, E.M. (Bowling Green State University, Bowling Green, OH), Briot, A.S, Doll, K.Z, Ludwiczak, R.L, Otteson, D.C, Tower, J, Vessey, K.B, Yu, K
Format: Article
Language:English
Subjects:
ADN
Alleles
Animals
ASCENDANCE
ASCENDENCIA
Biological and medical sciences
Chromosome Banding
Chromosome Mapping
Classical genetics, quantitative genetics, hybrids
DESARROLLO EMBRIONARIO
DEVELOPPEMENT EMBRYONNAIRE
Diptera
DIVISION CELLULAIRE
DIVISION CELULAR
DROSOPHILA
Drosophila - genetics
Drosophila melanogaster
Drosophilidae
ESTERILIDAD FEMENINA
EXPRESION GENICA
EXPRESSION DES GENES
Female
FENOTIPOS
Fundamental and applied biological sciences. Psychology
GENE
GENE RECESSIF
GENES
GENES RECESIVOS
Genes, Recessive
Genetic Complementation Test
GENETICA
Genetics of eukaryotes. Biological and molecular evolution
GENETIQUE
INFERTILITE FEMELLE
Invertebrata
Investigations
Male
MEMBRANAS FETALES
MEMBRANE FOETALE
MUTACION INDUCIDA
Mutagenesis
Mutation
MUTATION PROVOQUEE
PHENOTYPE
Reproduction - genetics
Temperature
Transcription, Genetic
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Description
Summary:Two genomic clones exhibiting a maternal-specific pattern of expression map to cytological region 52A. To elucidate the function of these clones we have undertaken a mutagenesis of the cytological region 51D-52A. This paper presents the results of this screen and the preliminary analysis of female-sterile and lethal mutations isolated. A total of twelve complementation groups have been identified, four of which are defined exclusively by female-sterile alleles. Only one visible mutation was isolated, a recessive temperature-sensitive allele of Thickened-arista (Ta(rts)). Several of the seven lethal loci display an embryonic lethal phase. Three of the four female-sterile loci affect chorion structure with one resulting in underamplification of the chorion genes, and two (possibly three) of the four female-steriles affect nuclear division/DNA replication. Thus it appears that this is a "developmentally important" region, possibly representing a clustering of genes involved in either DNA replication or nuclear division
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/126.3.639