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Mutations in the Yeast PDR3, PDR4, PDR7 and PDR9 Pleiotropic (Multiple) Drug Resistance Loci Affect the Transcript Level of an ATP Binding Cassette Transporter Encoding Gene, PDR5
The yeast pleiotropic (multiple drug) resistance gene PDR5 encodes a product with homology to a large number of membrane transport proteins including the mammalian multiple drug resistance family. In this study, we identified four genes on chromosome II that affect the steady-state level of PDR5 tra...
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| Published in: | Genetics (Austin) 1994-02, Vol.136 (2), p.505-515 |
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| Main Authors: | , , , |
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| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c552t-8db24f101bf16502b4547814f8fc8fb2ab1b32018cd7bc80c60826b189b49c713 |
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| container_end_page | 515 |
| container_issue | 2 |
| container_start_page | 505 |
| container_title | Genetics (Austin) |
| container_volume | 136 |
| creator | Dexter, D Moye-Rowley, W. S Wu, A. L Golin, J |
| description | The yeast pleiotropic (multiple drug) resistance gene PDR5 encodes a product with homology to a large number of membrane transport proteins including the mammalian multiple drug resistance family. In this study, we identified four genes on chromosome II that affect the steady-state level of PDR5 transcript in addition to a previously identified positive regulator, PDR1. The genes in question are PDR3, PDR4, PDR7 and PDR9. We also analyzed the interaction between PDR5 and YAP1. YAP1 encodes a positive regulator with a leucine zipper motif that causes pleiotropic drug resistance when overproduced. YAP1-mediated pleiotropic drug resistance is not dependent on the presence of PDR5 and must act through other genes. |
| doi_str_mv | 10.1093/genetics/136.2.505 |
| format | article |
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S ; Wu, A. L ; Golin, J</creator><creatorcontrib>Dexter, D ; Moye-Rowley, W. S ; Wu, A. L ; Golin, J</creatorcontrib><description>The yeast pleiotropic (multiple drug) resistance gene PDR5 encodes a product with homology to a large number of membrane transport proteins including the mammalian multiple drug resistance family. In this study, we identified four genes on chromosome II that affect the steady-state level of PDR5 transcript in addition to a previously identified positive regulator, PDR1. The genes in question are PDR3, PDR4, PDR7 and PDR9. We also analyzed the interaction between PDR5 and YAP1. YAP1 encodes a positive regulator with a leucine zipper motif that causes pleiotropic drug resistance when overproduced. YAP1-mediated pleiotropic drug resistance is not dependent on the presence of PDR5 and must act through other genes.</description><identifier>ISSN: 0016-6731</identifier><identifier>ISSN: 1943-2631</identifier><identifier>EISSN: 1943-2631</identifier><identifier>DOI: 10.1093/genetics/136.2.505</identifier><identifier>PMID: 8150279</identifier><identifier>CODEN: GENTAE</identifier><language>eng</language><publisher>United States: Genetics Soc America</publisher><subject>Adenosine Triphosphate - metabolism ; Alleles ; ATP-Binding Cassette Transporters ; Biochemistry ; Biological Transport, Active ; Carrier Proteins - genetics ; Carrier Proteins - metabolism ; Chromosome Mapping ; Chromosomes, Fungal ; Cycloheximide - pharmacology ; DNA-Binding Proteins - genetics ; DNA-Binding Proteins - metabolism ; Drug Resistance, Microbial - genetics ; Fungal Proteins - genetics ; Fungal Proteins - metabolism ; Gene Expression Regulation, Fungal ; Genes ; Genes, Fungal ; Genes, Regulator ; Investigations ; Leucine Zippers - genetics ; Membrane Proteins - genetics ; Membrane Proteins - metabolism ; Mutation ; Saccharomyces cerevisiae ; Saccharomyces cerevisiae - drug effects ; Saccharomyces cerevisiae - genetics ; Saccharomyces cerevisiae - metabolism ; Saccharomyces cerevisiae Proteins ; Sequence Deletion ; Trans-Activators ; Transcription Factors - genetics ; Transcription Factors - metabolism</subject><ispartof>Genetics (Austin), 1994-02, Vol.136 (2), p.505-515</ispartof><rights>Copyright Genetics Society of America Feb 1994</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c552t-8db24f101bf16502b4547814f8fc8fb2ab1b32018cd7bc80c60826b189b49c713</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,777,781,882,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8150279$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dexter, D</creatorcontrib><creatorcontrib>Moye-Rowley, W. 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L ; Golin, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c552t-8db24f101bf16502b4547814f8fc8fb2ab1b32018cd7bc80c60826b189b49c713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1994</creationdate><topic>Adenosine Triphosphate - metabolism</topic><topic>Alleles</topic><topic>ATP-Binding Cassette Transporters</topic><topic>Biochemistry</topic><topic>Biological Transport, Active</topic><topic>Carrier Proteins - genetics</topic><topic>Carrier Proteins - metabolism</topic><topic>Chromosome Mapping</topic><topic>Chromosomes, Fungal</topic><topic>Cycloheximide - pharmacology</topic><topic>DNA-Binding Proteins - genetics</topic><topic>DNA-Binding Proteins - metabolism</topic><topic>Drug Resistance, Microbial - genetics</topic><topic>Fungal Proteins - genetics</topic><topic>Fungal Proteins - metabolism</topic><topic>Gene Expression Regulation, Fungal</topic><topic>Genes</topic><topic>Genes, Fungal</topic><topic>Genes, Regulator</topic><topic>Investigations</topic><topic>Leucine Zippers - genetics</topic><topic>Membrane Proteins - genetics</topic><topic>Membrane Proteins - metabolism</topic><topic>Mutation</topic><topic>Saccharomyces cerevisiae</topic><topic>Saccharomyces cerevisiae - drug effects</topic><topic>Saccharomyces cerevisiae - genetics</topic><topic>Saccharomyces cerevisiae - metabolism</topic><topic>Saccharomyces cerevisiae Proteins</topic><topic>Sequence Deletion</topic><topic>Trans-Activators</topic><topic>Transcription Factors - genetics</topic><topic>Transcription Factors - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dexter, D</creatorcontrib><creatorcontrib>Moye-Rowley, W. 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The genes in question are PDR3, PDR4, PDR7 and PDR9. We also analyzed the interaction between PDR5 and YAP1. YAP1 encodes a positive regulator with a leucine zipper motif that causes pleiotropic drug resistance when overproduced. YAP1-mediated pleiotropic drug resistance is not dependent on the presence of PDR5 and must act through other genes.</abstract><cop>United States</cop><pub>Genetics Soc America</pub><pmid>8150279</pmid><doi>10.1093/genetics/136.2.505</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0016-6731 |
| ispartof | Genetics (Austin), 1994-02, Vol.136 (2), p.505-515 |
| issn | 0016-6731 1943-2631 1943-2631 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1205804 |
| source | Freely Accessible Science Journals - check A-Z of ejournals; Alma/SFX Local Collection |
| subjects | Adenosine Triphosphate - metabolism Alleles ATP-Binding Cassette Transporters Biochemistry Biological Transport, Active Carrier Proteins - genetics Carrier Proteins - metabolism Chromosome Mapping Chromosomes, Fungal Cycloheximide - pharmacology DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Drug Resistance, Microbial - genetics Fungal Proteins - genetics Fungal Proteins - metabolism Gene Expression Regulation, Fungal Genes Genes, Fungal Genes, Regulator Investigations Leucine Zippers - genetics Membrane Proteins - genetics Membrane Proteins - metabolism Mutation Saccharomyces cerevisiae Saccharomyces cerevisiae - drug effects Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Sequence Deletion Trans-Activators Transcription Factors - genetics Transcription Factors - metabolism |
| title | Mutations in the Yeast PDR3, PDR4, PDR7 and PDR9 Pleiotropic (Multiple) Drug Resistance Loci Affect the Transcript Level of an ATP Binding Cassette Transporter Encoding Gene, PDR5 |
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