Multilocus analysis for gene-centromere mapping using first polar bodies and secondary oocytes

Polar body and oocyte typing is a new technique for gene-centromere mapping and for generating female linkage maps. A maximum likelihood approach is presented for-ordering multiple markers relative to the centromere and for estimating recombination frequencies between markers and between the centrom...

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Bibliographic Details
Published in:Genetics (Austin) 1995-02, Vol.139 (2), p.1091-1097
Main Authors: Da, Y. (University of Illinois, Urbana, IL.), Jarrell, V.L, Wang, T, Fernando, R.L, Wheeler, M.B, Lewin, H.A
Format: Article
Language:English
Subjects:
ANALISIS ESTADISTICO
ANALYSE STATISTIQUE
Animals
Centromere
CHROMOSOME
Chromosome Mapping - methods
CROMOSOMAS
CROSSING OVER
Crossing Over, Genetic
CRUZAMIENTO INTERCROMOSOMICO
Female
FEMELLE
GENE
GENES
Genetic Linkage
Genetic Markers
Genetics
HEMBRA
Humans
Investigations
Likelihood Functions
MARCADORES GENETICOS
MARQUEUR GENETIQUE
Oocytes
OVULE
OVULO
RECOMBINACION
RECOMBINAISON
Recombination, Genetic
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Summary:Polar body and oocyte typing is a new technique for gene-centromere mapping and for generating female linkage maps. A maximum likelihood approach is presented for-ordering multiple markers relative to the centromere and for estimating recombination frequencies between markers and between the centromere and marker loci. Three marker-centromere orders are possible for each pair of markers: two orders when the centromere flanks the two markers and one order when the centromere is flanked by the two markers. For each possible order, the likelihood was expressed as a function of recombination frequencies for two adjacent intervals. LOD score for recombination frequency between markers or between the centromere and a marker locus was derived based on the likelihood for each gene-centromere order. The methods developed herein provide a general solution to the problem of multilocus gene-centromere mapping that involves all theoretical crossover possibilities, including four-strand double crossovers
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/139.2.1091