Evidence for an Inducible Repair-Recombination System in the Female Germ Line of Drosophila melanogaster. I. Induction by Inhibitors of Nucleotide Synthesis and by Gamma Rays

In the I-R system of hybrid dysgenesis in Drosophila melanogaster, the transposition frequency of I factor, a LINE element-like retrotransposon, is regulated by the reactivity level of the R mother. This reactivity is a cellular state maternally inherited but chromosomally determined, which has been...

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Bibliographic Details
Published in:Genetics (Austin) 1995-10, Vol.141 (2), p.571-578
Main Authors: Bregliano, J. C, Laurencon, A, Degroote, F
Format: Article
Language:English
Subjects:
Aging
Animals
Antimetabolites - pharmacology
Biochemistry
Cesium Radioisotopes
Deoxyribonucleic acid
DNA
DNA Repair - drug effects
DNA Repair - radiation effects
Dose-Response Relationship, Drug
Drosophila melanogaster
Drosophila melanogaster - genetics
Female
Fertility
Fertility - genetics
Gamma Rays
Genetics
Insects
Investigations
Kinetics
Life Sciences
Male
Methotrexate - pharmacology
Oocytes
Oocytes - physiology
Oviposition - radiation effects
Recombination, Genetic
Recombination, Genetic - drug effects
Recombination, Genetic - radiation effects
Retroelements
Time Factors
Uracil - analogs & derivatives
Uracil - pharmacology
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Summary:In the I-R system of hybrid dysgenesis in Drosophila melanogaster, the transposition frequency of I factor, a LINE element-like retrotransposon, is regulated by the reactivity level of the R mother. This reactivity is a cellular state maternally inherited but chromosomally determined, which has been shown to undergo heritable, cumulative and reversible changes with aging and some environmental conditions. We propose the hypothesis that this reactivity level is one manifestation of an inducible repair-recombination system whose biological role might be analogous to the SOS response in bacteria. In this paper, we show that inhibitors of DNA synthesis and gamma rays enhance the reactivity level in a very similar way. This enhancement is heritable, cumulative and reversible.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/141.2.571