Rearrangements involving repeated sequences within a P element preferentially occur between units close to the transposon extremities

In a previous report we described rearrangements occurring at a high rate (30% of the progeny of dysgenic flies) within a cluster of 5S genes internal to a P element. These events were characterized as precise amplifications and deletions of 5S units. Here we analyze recombination events within P el...

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Bibliographic Details
Published in:Genetics (Austin) 1996-02, Vol.142 (2), p.459-470
Main Authors: Paques, F, Bucheton, B, Wegnez, M
Format: Article
Language:English
Subjects:
Animals
ATP-Binding Cassette Transporters
color
compound eyes
deletions
dna amplification
DNA Transposable Elements
Drosophila melanogaster
Drosophila Proteins
duplication
Eye Color - genetics
Eye Proteins
Female
Gene Frequency
Gene Rearrangement
genetic change
genetic markers
genetic recombination
Genetics
Insect Hormones - genetics
Insects
Investigations
Male
Multigene Family
Mutagenesis, Insertional
Phenotype
repetitive sequences
Repetitive Sequences, Nucleic Acid
ribosomal DNA
Transformation, Genetic
transposition
transposons
white gene
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Summary:In a previous report we described rearrangements occurring at a high rate (30% of the progeny of dysgenic flies) within a cluster of 5S genes internal to a P element. These events were characterized as precise amplifications and deletions of 5S units. Here we analyze recombination events within P elements containing two repeated arrays of 5S genes flanking a central white gene. Deletions (50%) and duplications (3%) of the white gene together with various amounts of flanking 5S genes were observed. These recombinations occur preferentially between the most external 5S units of P transposons. Such rearrangements could be favored by interactions between the proteins bound to the P terminal sequences.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/142.2.459