Asm-1+, a Neurospora crassa gene related to transcriptional regulators of fungal development

This report describes the identification, cloning, and molecular analysis of Asm-1+ (Acospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. Th...

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Bibliographic Details
Published in:Genetics (Austin) 1996-11, Vol.144 (3), p.991-1003
Main Authors: Aramayo, R. (Stanford University, Stanford, CA.), Peleg, Y, Addison, R, Metzenberg, R
Format: Article
Language:English
Subjects:
ADN
Amino Acid Sequence
Base Sequence
Cell Nucleus - metabolism
CLONACION
CLONAGE
Cloning, Molecular
COMPOSICION QUIMICA
COMPOSITION CHIMIQUE
DIFERENCIACION CELULAR
DIFFERENCIATION CELLULAIRE
DNA, Fungal
ESPORAS
ESPORAS FUNGICAS
EXPRESION GENICA
EXPRESSION DES GENES
FENOTIPOS
Fungal Proteins
Fungi
Gene Deletion
Gene Expression Regulation, Fungal
Genes, Regulator
GENETICA
Genetics
GENETIQUE
GERMINACION
GERMINATION
IMMUNOLOGIE
INMUNOLOGIA
Investigations
MARCADORES GENETICOS
MARQUEUR GENETIQUE
Molecular biology
Molecular Sequence Data
MORFOLOGIA FUNGICA
MORPHOLOGIE DE CHAMPIGNON
MUTANT
MUTANTES
NEUROSPORA CRASSA
Neurospora crassa - genetics
Neurospora crassa - growth & development
PHENOTYPE
PROTEINAS AGLUTINANTES
PROTEINE DE LIAISON
Proteins
RFLP
SECUENCIA NUCLEOTIDICA
Sequence Homology, Amino Acid
SEQUENCE NUCLEOTIDIQUE
SPORE
SPORE FONGIQUE
TRANSCRIPCION
TRANSCRIPTION
Transcription Factors - genetics
Transcription Factors - metabolism
Transcription, Genetic
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Description
Summary:This report describes the identification, cloning, and molecular analysis of Asm-1+ (Acospore maturation 1), the Neurospora crassa homologue of the Aspergillus nidulans stuA (stunted A) gene. The Asm-1+ gene is constitutively transcribed and encodes an abundant, nucleus-localized 68.5-kD protein. The protein product of Asm-1+ (ASM-1), contains a potential DNA-binding motif present in related proteins from A. nidulans (StuA), Candida albicans (EFGTF-1), and Saccharomyces cerevisiae (Phd1 and Sok2). This motif is related to the DNA binding motif of the Swi4/Mbp1/Res family of transcription factors that control the cell cycle. Deletion of Asm-1+ destroys the ability to make protoperithecia (female organs), but does not affect male-specific functions. We propose that the APSES domain (ASM-1, Phd1, StuA, EFGTF-1, and Sok2) defines a group of proteins that constitute a family of related transcription factors involved in the control of fungal development
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/144.3.991