A COMPARISON OF SURVIVAL AND REPAIR OF UV-INDUCED DNA DAMAGE IN CULTURED INSECT VERSUS MAMMALIAN CELLS

Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79...

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Bibliographic Details
Published in:Genetics (Austin) 1977-11, Vol.87 (3), p.513-518
Main Authors: Koval, Thomas M, Hart, Ronald W, Myser, Willard C, Hink, Walter F
Format: Article
Language:English
Subjects:
Animals
Cell Survival
Cells, Cultured
Cricetinae
DNA - biosynthesis
DNA - radiation effects
DNA Repair
In Vitro Techniques
Insecta - genetics
Investigations
Time Factors
Ultraviolet Rays
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Summary:Survival and unscheduled DNA synthesis (UDS) were measured in a cultured insect cell line, TN-368, and a cultured mammalian cell line, V-79-4, following exposure to several fluences of ultraviolet light. TN-368 cells were approximately seven times more resistant to the lethal effects of UV than V-79 cells, as determined by colony formation. The amount of UDS per unit amount of DNA is about the same in both cell types 4 hr after 10-50 J/m2 UV irradiations.
ISSN:0016-6731
1943-2631
1943-2631
DOI:10.1093/genetics/87.3.513