In vitro glycoxidation alters the interactions between collagens and human polymorphonuclear leucocytes

Glycation and glycoxidation processes, which are increased in diabetes mellitus, are generally considered causative mechanisms of long-term complications. With reference to our previous studies, type-I and -IV collagens could induce differentially the adhesion and stimulation of polymorphonuclear le...

Full description

Saved in:
Bibliographic Details
Published in:Biochemical journal 2000-09, Vol.350 Pt 3 (3), p.777-783
Main Authors: Monboisse, J C, Rittie, L, Lamfarraj, H, Garnotel, R, Gillery, P
Format: Article
Language:English
Subjects:
Chemotaxis, Leukocyte
Collagen - metabolism
Glucose - metabolism
Humans
In Vitro Techniques
Neutrophil Activation
Neutrophils - cytology
Neutrophils - metabolism
Oxidation-Reduction
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Glycation and glycoxidation processes, which are increased in diabetes mellitus, are generally considered causative mechanisms of long-term complications. With reference to our previous studies, type-I and -IV collagens could induce differentially the adhesion and stimulation of polymorphonuclear leucocytes (PMNs). As PMNs play a role in sustained diabetic oxidative stress, the present study was designed to determine whether in vitro glycoxidation of these macromolecules could alter PMN adhesion, activation and migration. The adhesion of PMNs to in vitro-glycoxidized collagens was significantly increased when compared with control collagens: +37% (P
ISSN:0264-6021
1470-8728
DOI:10.1042/0264-6021:3500777