Peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency leads to dysregulation of hepatic lipid and carbohydrate metabolism by fatty acids and insulin

The aim of the present study was to determine whether peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency disrupts the normal regulation of triacylglycerol (TAG) accumulation, hepatic lipogenesis and glycogenesis by fatty acids and insulin using PPARalpha-null mice. In wild-type...

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Bibliographic Details
Published in:Biochemical journal 2002-06, Vol.364 (Pt 2), p.361-368
Main Authors: Sugden, Mary C, Bulmer, Karen, Gibbons, Geoffrey F, Knight, Brian L, Holness, Mark J
Format: Article
Language:English
Subjects:
Animals
Base Sequence
Carbohydrate Metabolism
CCAAT-Enhancer-Binding Proteins - genetics
DNA Primers
DNA-Binding Proteins - genetics
fas Receptor - genetics
Fatty Acids, Nonesterified - metabolism
Insulin - metabolism
Lipid Metabolism
Lipids - biosynthesis
Liver - metabolism
Mice
Mice, Knockout
Protein Kinases - metabolism
Protein-Serine-Threonine Kinases
Receptors, Cytoplasmic and Nuclear - genetics
Receptors, Cytoplasmic and Nuclear - physiology
RNA, Messenger - genetics
Starvation
Sterol Regulatory Element Binding Protein 1
Transcription Factors - genetics
Transcription Factors - physiology
Triglycerides - metabolism
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Summary:The aim of the present study was to determine whether peroxisome-proliferator-activated receptor-alpha (PPARalpha) deficiency disrupts the normal regulation of triacylglycerol (TAG) accumulation, hepatic lipogenesis and glycogenesis by fatty acids and insulin using PPARalpha-null mice. In wild-type mice, hepatic TAG concentrations increased (P
ISSN:0264-6021
1470-8728
DOI:10.1042/BJ20011699