Diffusion cannot govern the discharge of neurotransmitter in fast synapses

In the present work we show that diffusion cannot provide the observed fast discharge of neurotransmitter from a synaptic vesicle during neurotransmitter release, mainly because it is not sufficiently rapid nor is it sufficiently temperature-dependent. Modeling the discharge from the vesicle into th...

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Bibliographic Details
Published in:Biophysical journal 1994-09, Vol.67 (3), p.966-972
Main Authors: Khanin, R., Parnas, H., Segel, L.
Format: Article
Language:English
Subjects:
Animals
Biophysical Phenomena
Biophysics
Diffusion
Models, Neurological
Neurotransmitter Agents - secretion
Presynaptic Terminals - secretion
Quantum Theory
Synapses - secretion
Synaptic Vesicles - secretion
Temperature
Time Factors
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Summary:In the present work we show that diffusion cannot provide the observed fast discharge of neurotransmitter from a synaptic vesicle during neurotransmitter release, mainly because it is not sufficiently rapid nor is it sufficiently temperature-dependent. Modeling the discharge from the vesicle into the cleft as a continuous point source, we have determined that discharge should occur in 50–75 microseconds, to provide the observed high concentrations of transmitter at the critical zone.
ISSN:0006-3495
1542-0086
DOI:10.1016/S0006-3495(94)80562-4