Diagnosis and treatment of Amanita phalloides-type mushroom poisoning: use of thioctic acid

The number of cases of mushroom poisoning is increasing as a result of the increasing popularity of "wild" mushroom consumption. Amanitin and phalloidin cytotoxins found in some Amanita and Galerina species produce the most severe and frequent life-threatening symptoms of Amanita phalloide...

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Bibliographic Details
Published in:The Western journal of medicine 1976-08, Vol.125 (2), p.100-109
Main Authors: Becker, C E, Tong, T G, Boerner, U, Roe, R L, ScoTT, A T, MacQuarrie, M B, Bartter, F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Amanita
Animals
Child
Dogs
Female
Humans
Male
Middle Aged
Mushroom Poisoning - diagnosis
Mushroom Poisoning - drug therapy
Thioctic Acid - therapeutic use
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Summary:The number of cases of mushroom poisoning is increasing as a result of the increasing popularity of "wild" mushroom consumption. Amanitin and phalloidin cytotoxins found in some Amanita and Galerina species produce the most severe and frequent life-threatening symptoms of Amanita phalloidestype poisoning. Delay in onset of symptoms, individual susceptibility variation and lack of rapid and reliable identification have contributed to the significant morbidity and mortality of this type of poisoning.A rapid chromatographic assay for identifying the potent cytotoxins and apparently successful management using thioctic acid of two cases of A. phalloides-type mushroom poisoning are reported. All known cases of A. phalloides-type mushroom poisoning treated with thioctic acid in the United States are summarized.
ISSN:0093-0415