Porcine focal symmetrical poliomyelomalacia: experimental reproduction with oral doses of encapsulated sodium selenite

Sodium selenite (encapsulated as doses of 1.4 mg, 2.6 mg and 4.2 mg per kilogram of body weight) was given orally on a daily basis to male weaner pigs, and features of these animals were compared to a control group. Porcine focal symmetrical poliomyelomalacia was produced in all experimental groups...

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Bibliographic Details
Published in:Canadian journal of veterinary research 1988, Vol.52 (1), p.83-88
Main Authors: Wilson, T.M, Hammerstedt, R.H, Palmer, I.S, DeLahunta, A
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
Brain - pathology
diet
histopathology
Male
neurotoxins
Niacin - analysis
polioencephalomalacia
Selenious Acid
selenium
Selenium - administration & dosage
Selenium - adverse effects
Selenium - analysis
sodium
Spinal Cord - pathology
Spinal Cord Diseases - chemically induced
Spinal Cord Diseases - pathology
Spinal Cord Diseases - veterinary
Swine
Swine Diseases - chemically induced
Swine Diseases - pathology
toxicity
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Summary:Sodium selenite (encapsulated as doses of 1.4 mg, 2.6 mg and 4.2 mg per kilogram of body weight) was given orally on a daily basis to male weaner pigs, and features of these animals were compared to a control group. Porcine focal symmetrical poliomyelomalacia was produced in all experimental groups between 3 and 20 days after initiation of the treatment. Analysis of blood and several tissues revealed an elevated selenium content for all pigs. Histological lesions in the brain and the cervical lumbar/sacral spinal cord enlargements included endothelial proliferation, neuronal degeneration, microcavitation and glial cell reaction.
ISSN:0830-9000