Colitis in calves: natural and experimental infection with a verotoxin-producing strain of Escherichia coli O111:NM

• Published in: Canadian journal of veterinary research 1988-10, Vol.52 (4), p.484-487
• Main Authors: Schoonderwoerd, M, Clarke, R C, van Dreumel, A A, Rawluk, S A
• Format: Article
• Language: English
• Subjects: Animals; Bacterial Toxins; Cattle; Cattle Diseases - microbiology; Cattle Diseases - pathology; Colitis - microbiology; Colitis - pathology; Colitis - veterinary; Escherichia coli - classification; Escherichia coli Infections - pathology; Escherichia coli Infections - veterinary; Male; Shiga Toxin 1
• ISSN: 0830-9000

Verotoxin-producing Escherichia coli O111:NM were isolated from two five week old Holstein calves with dysentery. On necropsy both calves had pseudomembranous ileitis, mucohemorrhagic colitis and proctitis. Large numbers of E. coli O111:NM were isolated from the colon and lesions typical of attaching-and-effacing E. coli were evident. The isolates from both calves had identical biochemical reactions and antimicrobial resistance patterns. Oral inoculation of a four day old colostrum deprived calf with 1 x 10(10) organisms of E. coli O111:NM produced a mild, focal colitis with typical attachment and effacement lesions. We conclude that the strain of E. coli O111:NM isolated from the clinical cases has the ability to produce colitis characterized by attachment and effacement of the colonic mucosa.