Effect of deferoxamine pretreatment on acute pneumonic pasteurellosis and neutrophil oxidative metabolism in calves

Iron plays a central role in bacterial infections, influencing both bacterial virulence and host cellular defense mechanisms. We investigated whether iron chelation might be of benefit in the treatment of pneumonic pasteurellosis of calves. Neutrophils obtained from calves previously treated with th...

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Bibliographic Details
Published in:Canadian journal of veterinary research 1990-04, Vol.54 (2), p.227-231
Main Authors: Slocombe, R.F, Watson, G.L, Killingsworth, C.R
Format: Article
Language:English
Subjects:
Acute Disease
Animals
calves
Cattle
Cattle Diseases - drug therapy
chelation
deferoxamine
Deferoxamine - adverse effects
Deferoxamine - therapeutic use
dosage
hypoxia
iron
Iron - urine
Kidney - drug effects
kidneys
Mannheimia haemolytica
Neutrophils - metabolism
Oxidation-Reduction
Oxygen - blood
Pasteurella Infections - drug therapy
Pasteurella Infections - veterinary
pasteurellosis
pneumonia
Pneumonia - drug therapy
Pneumonia - veterinary
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Summary:Iron plays a central role in bacterial infections, influencing both bacterial virulence and host cellular defense mechanisms. We investigated whether iron chelation might be of benefit in the treatment of pneumonic pasteurellosis of calves. Neutrophils obtained from calves previously treated with the iron chelator, deferoxamine, were studied for their responses to latex and opsonized zymosan by luminol-enhanced chemiluminescence and to phorbol myristate acetate and opsonized zymosan by superoxide generation. Treatment with deferoxamine in vivo failed to influence these in vitro measures of neutrophil oxidative metabolism. Furthermore, iron depletion with deferoxamine failed to modify the pathophysiological derangements that occurred in calves following experimental induction of pneumonia by intratracheal inoculation with Pasteurella haemolytica. These data indicate that iron chelation using deferoxamine cannot be recommended as an adjunct to conventional therapy in the treatment of pneumonic pasteurellosis of cattle.
ISSN:0830-9000