Molecular mechanisms of autoimmunity triggered by microbial infection

Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopept...

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Bibliographic Details
Published in:Arthritis research & therapy 2005-01, Vol.7 (5), p.215-224
Main Authors: Anders, Hans-Joachim, Zecher, Daniel, Pawar, Rahul D, Patole, Prashant S
Format: Article
Language:English
Subjects:
Animals
Autoimmune Diseases - etiology
Autoimmune Diseases - immunology
Autoimmune Diseases - therapy
Bacterial Proteins - immunology
Chemokines - physiology
Cytokines - physiology
Dendritic Cells - immunology
Humans
Immune Tolerance
Infection - complications
Infection - immunology
Mice
Mice, Inbred Strains
Review
T-Lymphocytes - immunology
Toll-Like Receptors - physiology
Vertebrates - immunology
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Summary:Autoimmunity can be triggered by microbial infection. In this context, the discovery of Toll-like receptors (TLRs) provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules, including lipopeptides, lipopolysaccharides, and nucleic acids. They also have the potential, however, to trigger autoimmune disease, as has been revealed by an increasing number of experimental reports. This review summarizes important facts about TLR biology, available data on their role in autoimmunity, and potential consequences for the management of patients with autoimmune disease.
ISSN:1478-6354
1478-6362
DOI:10.1186/ar1818