Pharmacological relaxation of the urethra in male cats: a study of the effects of phenoxybenzamine, diazepam, nifedipine and xylazine

Urethral pressure profiles (UPPs) were recorded in ten adult healthy male cats before and after administration of either phenoxybenzamine, diazepam, nifedipine or xylazine. A significant decrease (p < 0.05) in urethral pressure at the level of the prostate was observed following treatment with al...

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Bibliographic Details
Published in:Canadian journal of veterinary research 1991, Vol.55 (1), p.28-32
Main Authors: Mawby, D.I, Meric, S.M, Crichlow, E.C, Papich, M.G
Format: Article
Language:English
Subjects:
Administration, Oral
Animals
cats
Cats - physiology
Diazepam - administration & dosage
Diazepam - pharmacology
drug effects
Injections, Intravenous - veterinary
Male
males
muscle relaxants
Muscle Relaxation - drug effects
muscle tissues
Muscle, Smooth - drug effects
Muscle, Smooth - physiology
Muscles - drug effects
Muscles - physiology
Nifedipine - administration & dosage
Nifedipine - pharmacology
Phenoxybenzamine - administration & dosage
Phenoxybenzamine - pharmacology
Pressure
prostate
Random Allocation
Restraint, Physical
smooth muscle
Space life sciences
spasms
urethra
Urethra - drug effects
Urethra - physiology
Urinary Catheterization - veterinary
Xylazine - administration & dosage
Xylazine - pharmacology
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Summary:Urethral pressure profiles (UPPs) were recorded in ten adult healthy male cats before and after administration of either phenoxybenzamine, diazepam, nifedipine or xylazine. A significant decrease (p < 0.05) in urethral pressure at the level of the prostate was observed following treatment with all drugs. Xylazine produced a significant decrease in urethral pressure 4 to 7 cm from the tip of the penis in healthy male cats. None of the drugs used decreased urethral pressure in the zones of pure striated muscle or pure smooth muscle in these cats, making current recommendations for pharmacological management of urethral spasm suspect. Further studies are necessary to evaluate clinical cases of urethral spasm and to study the effects of these drugs on the urethral pressure of cats suffering from this spasm.
ISSN:0830-9000