Studies with tryptophan metabolites in vitro: Kynurenine metabolism in liver homogenates of normal and

The conversion of kynurenine into kynurenic acid and anthranilic acid in both normal and Schistosoma mansoni -infested mouse liver was investigated. It was found that in the S. mansoni -infested mouse liver there is probably a deficiency of pyridoxal phosphate that resulted in an inhibition of kynur...

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Bibliographic Details
Published in:Biochemical journal 1967-08, Vol.104 (2), p.656-662
Main Authors: Amer, M. Samir, Abdel-Daim, M. H., Abdel-Tawab, G. A.
Format: Article
Language:English
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Summary:The conversion of kynurenine into kynurenic acid and anthranilic acid in both normal and Schistosoma mansoni -infested mouse liver was investigated. It was found that in the S. mansoni -infested mouse liver there is probably a deficiency of pyridoxal phosphate that resulted in an inhibition of kynurenine transaminase and a low production of kynurenic acid. Deoxypyridoxine and its phosphorylated derivative inhibited kynurenine transaminase in the normal liver in a pattern qualitatively similar to that observed with infested liver. The lowered concentration of pyridoxal phosphate in the infested liver is discussed in view of the possibility of two combined mechanisms: ( a ) an antimetabolite being secreted by the infesting worms or present in its eggs that partially inhibited the phosphorylation of pyridoxal, and ( b ) concentration of pyridoxal phosphate by the worms, resulting in a lowered concentration of the cofactor in the host tissue.
ISSN:0264-6021
1470-8728