Frequency of XY Sperm Increases with Age in Fathers of Boys with Klinefelter Syndrome

With increasing availability of drugs for impotence and advanced reproductive technologies for the treatment of subfertility, more men are fathering children at advanced ages. We conducted a study of the chromosomal content of sperm of healthy men aged 24–57 years to ( a) determine whether father’s...

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Bibliographic Details
Published in:American journal of human genetics 2001-11, Vol.69 (5), p.1046-1054
Main Authors: Lowe, Xiu, Eskenazi, Brenda, Nelson, David O., Kidd, Sharon, Alme, Angela, Wyrobek, Andrew J.
Format: Article
Language:English
Subjects:
Adult
Aging - genetics
Aneuploidy
Biological and medical sciences
Child
Fathers
Gynecology. Andrology. Obstetrics
Humans
In Situ Hybridization, Fluorescence
Klinefelter Syndrome - genetics
Male
Male and female genital diseases. Gonadal dysgenesis. Hermaphroditism. Sex hormones resistance
Medical sciences
Meiosis - genetics
Middle Aged
Spermatozoa - cytology
Spermatozoa - metabolism
Trisomy - genetics
X Chromosome - genetics
Y Chromosome - genetics
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Summary:With increasing availability of drugs for impotence and advanced reproductive technologies for the treatment of subfertility, more men are fathering children at advanced ages. We conducted a study of the chromosomal content of sperm of healthy men aged 24–57 years to ( a) determine whether father’s age was associated with increasing frequencies of aneuploid sperm including XY, disomy X, disomy Y, disomy 21, and sperm diploidy, and ( b) examine the association between the frequencies of disomy 21 and sex-chromosomal aneuploidies. The study group consisted of 38 fathers of boys with Klinefelter syndrome (47, XXY) recruited nationwide, and sperm aneuploidy was assessed using multicolor X-Y-21 sperm FISH (∼10,000 sperm per donor). Paternal age was significantly correlated with the sex ratio of sperm (Y/X; P=.006) and with the frequency of XY sperm ( P=.02), with a clear trend with age by decades ( P
ISSN:0002-9297
1537-6605
DOI:10.1086/323763