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Influence of agonists on desensitization of glutamate receptors on locust muscle
1. The desensitization, by ionophoretically and bath-applied L-glutamate and agonists, of excitatory post-junctional receptor populations on locust extensor tibiae muscle was investigated. 2. The kinetics of onset of and recovery from desensitization were determined ionophoretically either with trai...
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| Published in: | The Journal of physiology 1981-03, Vol.312 (1), p.345-364 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 364 |
| container_issue | 1 |
| container_start_page | 345 |
| container_title | The Journal of physiology |
| container_volume | 312 |
| creator | Anis, N A Clark, R B Gration, K A Usherwood, P N |
| description | 1. The desensitization, by ionophoretically and bath-applied L-glutamate and agonists, of excitatory post-junctional receptor
populations on locust extensor tibiae muscle was investigated. 2. The kinetics of onset of and recovery from desensitization
were determined ionophoretically either with trains of glutamate/agonist pulses of different frequencies ('conditioning trains')
followed by a single 'test' pulse at different intervals after cessation of the conditioning train or with trains of constant
frequency drug pulses superimposed upon steady 'conditioning' doses. Both methods gave quantitatively similar results. 3.
For approximately equipotent doses, L-glutamate and agonists produced different rates of desensitization onset. Qualitatively
similar results were obtained when changes in input conductance of single muscle fibres were measured during bath application
of the amino acids. 4. The time courses of recovery from desensitization for receptor populations activated by glutamate and
agonists could be described adequately by single exponentials and were independent of the concentration of amino acid except
when desensitization exceeded ca. 90%. 5. The rate of recovery from desensitization was different for each agonist. |
| doi_str_mv | 10.1113/jphysiol.1981.sp013632 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1275557</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>73600738</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5005-3dd459a583d5327e0c7d6b18d22573218429f26f7f194b38f8195bd19369731f3</originalsourceid><addsrcrecordid>eNqNkUFv1DAQhS0EKtuFnwDKCU5ZPHYcxxckqCgUVaKHcra8zmTXlRMH26Fafj1Zsq3gxsmy3_fejPwIeQ10AwD83d24PyQX_AZUA5s0UuA1Z0_ICqpalVIq_pSsKGWs5FLAc3Ke0h2dIarUGTmTrK6Ualbk5mro_ISDxSJ0hdmFwaWcijAULSYcksvul8luvs_yzk_Z9CZjEdHimEP8Q_pgp5SLfkrW4wvyrDM-4cvTuSbfLz_dXnwpr799vrr4cF1aQakoedtWQhnR8FZwJpFa2dZbaFrGhOQMmoqpjtWd7EBVW950DSixbUHxWkkOHV-T90vuOG17bC0OORqvx-h6Ew86GKf_VQa317vwUwOTQswz1uTNKSCGHxOmrHuXLHpvBgxT0pLXlErezGC9gDaGlCJ2j0OA6mMX-qELfexCP3QxG1_9veKj7fT5s_5x0e-dx8N_purbrzfHBw4MeCXmkLdLyN7t9vcuol5sKViH-aBnToM-kr8Btp-sfA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>73600738</pqid></control><display><type>article</type><title>Influence of agonists on desensitization of glutamate receptors on locust muscle</title><source>PubMed Central</source><creator>Anis, N A ; Clark, R B ; Gration, K A ; Usherwood, P N</creator><creatorcontrib>Anis, N A ; Clark, R B ; Gration, K A ; Usherwood, P N</creatorcontrib><description>1. The desensitization, by ionophoretically and bath-applied L-glutamate and agonists, of excitatory post-junctional receptor
populations on locust extensor tibiae muscle was investigated. 2. The kinetics of onset of and recovery from desensitization
were determined ionophoretically either with trains of glutamate/agonist pulses of different frequencies ('conditioning trains')
followed by a single 'test' pulse at different intervals after cessation of the conditioning train or with trains of constant
frequency drug pulses superimposed upon steady 'conditioning' doses. Both methods gave quantitatively similar results. 3.
For approximately equipotent doses, L-glutamate and agonists produced different rates of desensitization onset. Qualitatively
similar results were obtained when changes in input conductance of single muscle fibres were measured during bath application
of the amino acids. 4. The time courses of recovery from desensitization for receptor populations activated by glutamate and
agonists could be described adequately by single exponentials and were independent of the concentration of amino acid except
when desensitization exceeded ca. 90%. 5. The rate of recovery from desensitization was different for each agonist.</description><identifier>ISSN: 0022-3751</identifier><identifier>EISSN: 1469-7793</identifier><identifier>DOI: 10.1113/jphysiol.1981.sp013632</identifier><identifier>PMID: 7264998</identifier><language>eng</language><publisher>England: The Physiological Society</publisher><subject>Animals ; Excitatory Amino Acid Antagonists ; Glutamates - pharmacology ; Glutamates - physiology ; Grasshoppers ; In Vitro Techniques ; Kinetics ; Membrane Potentials - drug effects ; Muscles - innervation ; Receptors, Drug - physiology</subject><ispartof>The Journal of physiology, 1981-03, Vol.312 (1), p.345-364</ispartof><rights>1981 The Physiological Society</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5005-3dd459a583d5327e0c7d6b18d22573218429f26f7f194b38f8195bd19369731f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1275557/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1275557/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27915,27916,53782,53784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7264998$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Anis, N A</creatorcontrib><creatorcontrib>Clark, R B</creatorcontrib><creatorcontrib>Gration, K A</creatorcontrib><creatorcontrib>Usherwood, P N</creatorcontrib><title>Influence of agonists on desensitization of glutamate receptors on locust muscle</title><title>The Journal of physiology</title><addtitle>J Physiol</addtitle><description>1. The desensitization, by ionophoretically and bath-applied L-glutamate and agonists, of excitatory post-junctional receptor
populations on locust extensor tibiae muscle was investigated. 2. The kinetics of onset of and recovery from desensitization
were determined ionophoretically either with trains of glutamate/agonist pulses of different frequencies ('conditioning trains')
followed by a single 'test' pulse at different intervals after cessation of the conditioning train or with trains of constant
frequency drug pulses superimposed upon steady 'conditioning' doses. Both methods gave quantitatively similar results. 3.
For approximately equipotent doses, L-glutamate and agonists produced different rates of desensitization onset. Qualitatively
similar results were obtained when changes in input conductance of single muscle fibres were measured during bath application
of the amino acids. 4. The time courses of recovery from desensitization for receptor populations activated by glutamate and
agonists could be described adequately by single exponentials and were independent of the concentration of amino acid except
when desensitization exceeded ca. 90%. 5. The rate of recovery from desensitization was different for each agonist.</description><subject>Animals</subject><subject>Excitatory Amino Acid Antagonists</subject><subject>Glutamates - pharmacology</subject><subject>Glutamates - physiology</subject><subject>Grasshoppers</subject><subject>In Vitro Techniques</subject><subject>Kinetics</subject><subject>Membrane Potentials - drug effects</subject><subject>Muscles - innervation</subject><subject>Receptors, Drug - physiology</subject><issn>0022-3751</issn><issn>1469-7793</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1981</creationdate><recordtype>article</recordtype><recordid>eNqNkUFv1DAQhS0EKtuFnwDKCU5ZPHYcxxckqCgUVaKHcra8zmTXlRMH26Fafj1Zsq3gxsmy3_fejPwIeQ10AwD83d24PyQX_AZUA5s0UuA1Z0_ICqpalVIq_pSsKGWs5FLAc3Ke0h2dIarUGTmTrK6Ualbk5mro_ISDxSJ0hdmFwaWcijAULSYcksvul8luvs_yzk_Z9CZjEdHimEP8Q_pgp5SLfkrW4wvyrDM-4cvTuSbfLz_dXnwpr799vrr4cF1aQakoedtWQhnR8FZwJpFa2dZbaFrGhOQMmoqpjtWd7EBVW950DSixbUHxWkkOHV-T90vuOG17bC0OORqvx-h6Ew86GKf_VQa317vwUwOTQswz1uTNKSCGHxOmrHuXLHpvBgxT0pLXlErezGC9gDaGlCJ2j0OA6mMX-qELfexCP3QxG1_9veKj7fT5s_5x0e-dx8N_purbrzfHBw4MeCXmkLdLyN7t9vcuol5sKViH-aBnToM-kr8Btp-sfA</recordid><startdate>19810301</startdate><enddate>19810301</enddate><creator>Anis, N A</creator><creator>Clark, R B</creator><creator>Gration, K A</creator><creator>Usherwood, P N</creator><general>The Physiological Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19810301</creationdate><title>Influence of agonists on desensitization of glutamate receptors on locust muscle</title><author>Anis, N A ; Clark, R B ; Gration, K A ; Usherwood, P N</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5005-3dd459a583d5327e0c7d6b18d22573218429f26f7f194b38f8195bd19369731f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1981</creationdate><topic>Animals</topic><topic>Excitatory Amino Acid Antagonists</topic><topic>Glutamates - pharmacology</topic><topic>Glutamates - physiology</topic><topic>Grasshoppers</topic><topic>In Vitro Techniques</topic><topic>Kinetics</topic><topic>Membrane Potentials - drug effects</topic><topic>Muscles - innervation</topic><topic>Receptors, Drug - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Anis, N A</creatorcontrib><creatorcontrib>Clark, R B</creatorcontrib><creatorcontrib>Gration, K A</creatorcontrib><creatorcontrib>Usherwood, P N</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The Journal of physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Anis, N A</au><au>Clark, R B</au><au>Gration, K A</au><au>Usherwood, P N</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of agonists on desensitization of glutamate receptors on locust muscle</atitle><jtitle>The Journal of physiology</jtitle><addtitle>J Physiol</addtitle><date>1981-03-01</date><risdate>1981</risdate><volume>312</volume><issue>1</issue><spage>345</spage><epage>364</epage><pages>345-364</pages><issn>0022-3751</issn><eissn>1469-7793</eissn><abstract>1. The desensitization, by ionophoretically and bath-applied L-glutamate and agonists, of excitatory post-junctional receptor
populations on locust extensor tibiae muscle was investigated. 2. The kinetics of onset of and recovery from desensitization
were determined ionophoretically either with trains of glutamate/agonist pulses of different frequencies ('conditioning trains')
followed by a single 'test' pulse at different intervals after cessation of the conditioning train or with trains of constant
frequency drug pulses superimposed upon steady 'conditioning' doses. Both methods gave quantitatively similar results. 3.
For approximately equipotent doses, L-glutamate and agonists produced different rates of desensitization onset. Qualitatively
similar results were obtained when changes in input conductance of single muscle fibres were measured during bath application
of the amino acids. 4. The time courses of recovery from desensitization for receptor populations activated by glutamate and
agonists could be described adequately by single exponentials and were independent of the concentration of amino acid except
when desensitization exceeded ca. 90%. 5. The rate of recovery from desensitization was different for each agonist.</abstract><cop>England</cop><pub>The Physiological Society</pub><pmid>7264998</pmid><doi>10.1113/jphysiol.1981.sp013632</doi><tpages>20</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | The Journal of physiology, 1981-03, Vol.312 (1), p.345-364 |
| issn | 0022-3751 1469-7793 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1275557 |
| source | PubMed Central |
| subjects | Animals Excitatory Amino Acid Antagonists Glutamates - pharmacology Glutamates - physiology Grasshoppers In Vitro Techniques Kinetics Membrane Potentials - drug effects Muscles - innervation Receptors, Drug - physiology |
| title | Influence of agonists on desensitization of glutamate receptors on locust muscle |
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